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中国精品科技期刊2020
程真,魏文文,边媛媛,等. 负载花色苷的脂质体-阿拉伯树胶纳米颗粒体外稳定性与降脂活性分析[J]. 食品工业科技,2024,45(20):87−97. doi: 10.13386/j.issn1002-0306.2023110294.
引用本文: 程真,魏文文,边媛媛,等. 负载花色苷的脂质体-阿拉伯树胶纳米颗粒体外稳定性与降脂活性分析[J]. 食品工业科技,2024,45(20):87−97. doi: 10.13386/j.issn1002-0306.2023110294.
CHENG Zhen, WEI Wenwen, BIAN Yuanyuan, et al. In Vitro Stability and Lipid-lowering Activity Analysis of Liposome/Gum Arabic Nanoparticles Loaded with Anthocyanins[J]. Science and Technology of Food Industry, 2024, 45(20): 87−97. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023110294.
Citation: CHENG Zhen, WEI Wenwen, BIAN Yuanyuan, et al. In Vitro Stability and Lipid-lowering Activity Analysis of Liposome/Gum Arabic Nanoparticles Loaded with Anthocyanins[J]. Science and Technology of Food Industry, 2024, 45(20): 87−97. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023110294.

负载花色苷的脂质体-阿拉伯树胶纳米颗粒体外稳定性与降脂活性分析

In Vitro Stability and Lipid-lowering Activity Analysis of Liposome/Gum Arabic Nanoparticles Loaded with Anthocyanins

  • 摘要: 为解决花色苷(Anthocyanins,ACNs)在加工过程中易降解、体内生物利用度低及其在精准营养领域应用的限制性问题。本研究制备了以ACNs为核,以大豆卵磷脂构建的脂质体(Liposome,Lipo)和阿拉伯树胶(Gum Arabic,GA)为载体的ACNs纳米颗粒,即脂质体/阿拉伯树胶-花色苷(Lipo/GA-ACNs)纳米颗粒,考察环境因素和体外模拟消化对不同配方的Lipo/GA-ACNs纳米颗粒稳定性的影响,消化后Lipo/GA-ACNs纳米颗粒的体外降脂活性。结果表明,Lipo/GA-ACNs纳米颗粒在模拟热加工和不同离子环境下具有较好的稳定性;当ACNs与GA的质量比为1:10时,经模拟消化后,Lipo/GA-ACNs纳米颗粒对HepG-2细胞脂滴积聚和活性氧堆积的抑制效果分别比ACNs提高了3.8%和1.99%。因此,Lipo/1.0GA有望成为递送ACNs并实现肝脏降脂的有效口服运输体系,具备开发成具有精准营养性质的功能食品的潜力。

     

    Abstract: To address the issues of low bioavailability, degradation during processing, and limited use in precision nutrition of anthocyanins (ACNs). ACNs nanoparticles using ACNs as the core, soybean lecithin constructed-Liposome (Lipo), and Gum Arabic (GA) as the carrier were prepared in this study, namely Liposome/Gum Arabic-anthocyanins (Lipo/GA-ACNs) nanoparticles. In this study, nanoparticles of ACNs with ACNs as the core and liposomes (Lipo) constructed using soy lecithin and gum arabic (GA) as carriers, namely liposome/gum arabic-anthocyanins (Lipo/GA-ACNs) nanoparticles, were prepared. Environmental factors and in vitro simulated digestion on the stability of Lipo/GA-ACNs nanoparticles with various formulations were investigated. Additionally, the in vitro lipid-lowering activity of Lipo/GA-ACNs nanoparticles after digestion was examined. Results showed that Lipo/GA-ACNs nanoparticles had good stability under simulated thermal processing and different ion environments. When the ACNs to GA mass ratio was 1:10, the Lipo/GA-ACNs nanoparticles inhibited lipid droplet accumulation and reactive oxygen species accumulation in HepG-2 cells 3.8% and 1.99% more effectively than ACNs after simulated digestion. This study concluded that Lipo/1.0GA was a promising oral delivery system to deliver ACNs and achieve liver lipid-lowering, with the potential to be developed into functional foods with precision nutritional properties.

     

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