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中国精品科技期刊2020
董奇奇,张怡琳,游春苹. 肠道微生物及其代谢产物对血脑屏障的影响及益生菌干预措施研究进展[J]. 食品工业科技,2024,45(22):1−8. doi: 10.13386/j.issn1002-0306.2023120146.
引用本文: 董奇奇,张怡琳,游春苹. 肠道微生物及其代谢产物对血脑屏障的影响及益生菌干预措施研究进展[J]. 食品工业科技,2024,45(22):1−8. doi: 10.13386/j.issn1002-0306.2023120146.
DONG Qiqi, ZHANG Yilin, YOU Chunping. Research Progress in Effects of Gut Microbiota and Their Metabolites on the Blood-brain Barrier and Interventions by Probiotics[J]. Science and Technology of Food Industry, 2024, 45(22): 1−8. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023120146.
Citation: DONG Qiqi, ZHANG Yilin, YOU Chunping. Research Progress in Effects of Gut Microbiota and Their Metabolites on the Blood-brain Barrier and Interventions by Probiotics[J]. Science and Technology of Food Industry, 2024, 45(22): 1−8. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023120146.

肠道微生物及其代谢产物对血脑屏障的影响及益生菌干预措施研究进展

Research Progress in Effects of Gut Microbiota and Their Metabolites on the Blood-brain Barrier and Interventions by Probiotics

  • 摘要: 血脑屏障(blood-brain barrier,BBB)是中枢神经系统和外周循环之间独特的解剖和生理界面,对于维持中枢神经系统的稳定性至关重要。本文概述了血脑屏障在衰老、神经系统疾病和癌症等疾病发展过程中结构的变化情况,重点阐述了肠道微生物及其代谢产物对BBB的影响。环境因素引起的肠道菌群组成的改变通过多种途径破坏BBB完整性,而肠道微生物代谢产物则对BBB有正向、负向或双向调节作用。例如脂多糖和疏水性胆汁酸通过破坏细胞结构,降低紧密连接蛋白表达以及加重炎症反应,而对BBB产生负向作用;短链脂肪酸、3-吲哚丙酸和亲水性胆汁酸通过调节肠道菌群,提高紧密连接蛋白表达,减轻炎症和发挥抗氧化效果,而对BBB产生正向作用;而氧化三甲胺则对BBB有双向调节作用。此外,介绍了不同益生菌菌株通过改变肠道菌群组成,调节短链脂肪酸水平,提高紧密连接蛋白表达以及抗炎、抗氧化等途径直接或间接改善BBB完整性。本文为治疗和改善神经系统疾病提供新的策略和理论资料。

     

    Abstract: The blood-brain barrier (BBB) is a unique anatomical and physiological interface between the central nervous system (CNS) and the peripheral circulation, and is critical for maintaining CNS stability. This article provides an overview of the changes in the structure of the blood-brain barrier during the progression of diseases such as aging, neurological disorders, and cancer, with a focus on the effects of gut microbiota and their metabolites on the BBB. Environmental factor-induced changes in the composition of the gut flora disrupt BBB integrity through multiple pathways, whereas gut microbial metabolites have positive, negative, or bidirectional modulatory effects on the BBB. For example, lipopolysaccharide and hydrophobic bile acids have negative effects on the BBB by disrupting cellular structure, decreasing tight junction protein expression, and exacerbating inflammatory responses. The short chain fatty acids, 3-indolepropionic acid, and hydrophilic bile acids have positive effects on the BBB by regulating the intestinal flora, increasing tight junction protein expression, reducing inflammation and exerting antioxidant effects. The trimethylamine oxide has a two-way regulatory effects on the BBB. In addition, different probiotic strains are described to directly or indirectly improve BBB integrity by altering the composition of the intestinal flora, regulating short chain fatty acid levels, enhancing tight junction protein expression, as well as anti-inflammatory and antioxidant pathways. This article provides new strategies and theoretical materials for the treatment and improvement of neurological diseases.

     

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