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中国精品科技期刊2020
陈秋宇,赵然,孟美杉,等. 海洋硫酸多糖的免疫调节活性研究进展[J]. 食品工业科技,2025,46(1):1−11. doi: 10.13386/j.issn1002-0306.2024020170.
引用本文: 陈秋宇,赵然,孟美杉,等. 海洋硫酸多糖的免疫调节活性研究进展[J]. 食品工业科技,2025,46(1):1−11. doi: 10.13386/j.issn1002-0306.2024020170.
CHEN Qiuyu, ZHAO Ran, MENG Meishan, et al. Research Progress on Immune Regulation Activities of Marine Sulfate Polysaccharides[J]. Science and Technology of Food Industry, 2025, 46(1): 1−11. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024020170.
Citation: CHEN Qiuyu, ZHAO Ran, MENG Meishan, et al. Research Progress on Immune Regulation Activities of Marine Sulfate Polysaccharides[J]. Science and Technology of Food Industry, 2025, 46(1): 1−11. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024020170.

海洋硫酸多糖的免疫调节活性研究进展

Research Progress on Immune Regulation Activities of Marine Sulfate Polysaccharides

  • 摘要: 随着现代生活方式的改变,免疫力低下成为了越来越多人面临的健康问题,开发具有免疫调节活性的天然活性产物成为当前研究的热点问题之一。海洋硫酸多糖是从海洋生物中提取分离的一种富含硫酸基团的天然活性产物,其结构独特,在免疫调节活性方面展现了巨大潜力。为了更好地研究海洋硫酸多糖对免疫调节活性的影响及机制,本文对目前有关海洋硫酸多糖的研究文献进行分析和总结,根据结构及来源对海洋硫酸多糖的种类进行概述,重点从调节巨噬细胞、自然杀伤细胞、T/B淋巴细胞、补体系统和肠道微生物功能五个方面,综述海洋硫酸多糖发挥免疫调节活性的作用及机制。本文为海洋硫酸多糖的免疫调节活性及作用机制等后续研究提供理论基础,为开发新型海洋硫酸多糖免疫增强剂提供新思路,未来有望开发基于海洋硫酸多糖的针对免疫力低下、肿瘤和自身免疫性疾病的功能性食品或特殊医学用途食品,对食品行业的发展和人类的健康起到积极推动作用。

     

    Abstract: With changes in modern lifestyles, weakened immunity becomes a health problem for an increasing number of people. The development of natural active products with immunomodulatory activity becomes a popular research topic. Marine sulfated polysaccharides are natural active products that are rich in sulfate groups and are extracted and isolated from marine organisms. They have a unique structure and multiple biological activities and have shown great potential with regard to having immune regulatory activity. To better understand the effects of marine sulfated polysaccharides on immune regulatory activity and the associated underlying mechanisms, this article was designed to analyse and summarize the current research literature on marine sulfated polysaccharides. The types of marine sulfated polysaccharides are summarized based on their structure and source, with a focus on functions involving regulating macrophages, natural killer cells, T/B lymphocytes, complement systems, and gut microbiota. The immune regulatory activity of marine sulfated polysaccharides and the underlying mechanisms are summarized. This article provides a theoretical basis for subsequent research on the immunomodulatory activity and structure-activity relationships of marine sulfated polysaccharides and provides novel ideas for the development of new marine sulfated polysaccharide immunoenhancers. In the future, functional foods or special medical foods based on marine sulfated polysaccharides designed to treat immune deficiency, tumours, and autoimmune diseases may be developed, and these foods will play a positive role in promoting the development of the food industry and human health.

     

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