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中国精品科技期刊2020
陈琪,陈珂玉,王一凡,等. 神秘果干预肿瘤免疫的潜在机制研究[J]. 食品工业科技,2021,42(23):8−19. doi: 10.13386/j.issn1002-0306.2021040035.
引用本文: 陈琪,陈珂玉,王一凡,等. 神秘果干预肿瘤免疫的潜在机制研究[J]. 食品工业科技,2021,42(23):8−19. doi: 10.13386/j.issn1002-0306.2021040035.
CHEN Qi, CHEN Keyu, WANG Yifan, et al. Study on the Potential Mechanism of Synsepalum dulcificum Interfering with Tumor Immunity[J]. Science and Technology of Food Industry, 2021, 42(23): 8−19. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021040035.
Citation: CHEN Qi, CHEN Keyu, WANG Yifan, et al. Study on the Potential Mechanism of Synsepalum dulcificum Interfering with Tumor Immunity[J]. Science and Technology of Food Industry, 2021, 42(23): 8−19. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021040035.

神秘果干预肿瘤免疫的潜在机制研究

Study on the Potential Mechanism of Synsepalum dulcificum Interfering with Tumor Immunity

  • 摘要: 目的:研究神秘果干预肿瘤免疫药效学物质基础依据以及可能机制。方法:利用液相-质谱分析明确神秘果的成分,之后利用网络药理学以及生物信息学方法系统研究了神秘果作用于肿瘤免疫的作用靶点,同时明确神秘果药食同源的可能性。结果:液相-质谱实验得到神秘果的可能含有成分360种,与肿瘤免疫数据库对比后得到可干预肿瘤免疫相关成分42个,干预相关靶点55个,筛选后得到靶点网络中关键靶点为TSHR、TP53、MAPK1、HIF1A、CA9。进一步收集文献中实验信息及分子对接实验验证神秘果的不同成分可影响选取靶点进而干预肿瘤免疫。结论:通过以上实验发现神秘果成分与肿瘤免疫相关靶点可能具有相互作用,为神秘果直接作用肿瘤研究铺垫基础。

     

    Abstract: Objective: To study the material basis and possible mechanism of the pharmacodynamics of Synsepalum dulcificum's intervention in tumor immunity. Methods: The study used liquid phase-mass spectrometry analysis to clarify the composition of Synsepalum dulcificum, and then used the network pharmacology and bioinformatics methods to systematically study the specific impact of Synsepalum dulcificum on tumor immunity. At the same time, it was clear that Synsepalum dulcificum medicine and food were homologous.Results: The liquid-mass spectrometry experiment revealed that Synsepalum dulcificum may contain 360 components. After comparing with the tumor immunity database, 42 components related to tumor immunity and 55 related targets were obtained. After screening, key targets in the target network were obtained. These were TSHR, TP53, MAPK1, HIF1A, CA9. Further collection of experimental information in the literature and molecular docking experiments verified that the different components of Synsepalum dulcificum could affect the selection of targets and interfere with tumor immunity. Conclusion: Through the above experiments, it is found that the components of Synsepalum dulcificum may interact with tumor immune-related targets, paving the way for the research on the direct effect of Synsepalum dulcificum on tumors.

     

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