Effects of okra extract on blood glucose and lipids in type 2 diabetes mellitus rats

ZHANG Ling- min; WANG Ling; JIA Ao; JIA Lu

doi:10.13386/j.issn1002-0306.2016.03.066

Article Contents

Article Navigation > Science and Technology of Food Industry > 2016 > (03): 355-358

ZHANG Ling- min, WANG Ling, JIA Ao, JIA Lu. Effects of okra extract on blood glucose and lipids in type 2 diabetes mellitus rats[J]. Science and Technology of Food Industry, 2016, (03): 355-358. doi: 10.13386/j.issn1002-0306.2016.03.066

Citation:

ZHANG Ling- min, WANG Ling, JIA Ao, JIA Lu. Effects of okra extract on blood glucose and lipids in type 2 diabetes mellitus rats[J]. Science and Technology of Food Industry, 2016, (03): 355-358. doi: 10.13386/j.issn1002-0306.2016.03.066

Citation:

PDF( 934 KB)

Effects of okra extract on blood glucose and lipids in type 2 diabetes mellitus rats

doi: 10.13386/j.issn1002-0306.2016.03.066

Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University
School of Pharmaceutical Sciences,Zhengzhou University

Received Date: 2015-06-29

Abstract

Abstract

Objective: To explore the effects of the aqueous extract of okra on the blood glucose and lipid profiles in type 2 diabetes mellitus( T2DM) rats.Methods: The male SD rats were randomly divided into normal control group and experimental groups according to the body weight.The rats in the two groups were fed with lab chow and high- sugar and high- fat diet respectively. After four weeks of feeding,the rats in the experimental group received peritoneal injection of streptozotocin( STZ). Based on the glucose level,the succeed model rats were randomly re- grouped as blank control,positive control( Jiangtangning gavage,0.64 g / kg),high,middle,and low dose of okra extract groups( the okra extract was added into the high fat diet at the dosages of 2.60 g / kg,1.56 g / kg,and0.78 g / kg respectively).The experiment lasted for four weeks.Body weight,average levels of food and water,and blood glucose level were measured weekly.At the end of experiment,the blood samples of the rats were collected and analyzed for serum glucose,triglyceride( TG),total cholesterol( TC),high density lipoprotein cholesterol( HDL-C),and low density lipoprotein cholesterol( LDL- C).Results: The serum glucose was lower in the rats of high dose group than that in blank control group and low does group( p < 0.05,p < 0.05).Serum TC was lower in all okra feeding groups of rats than those in blank control group( p < 0.01).Serum LDL- C level was lower in high dose group rats than that in blank control group( p < 0.01). Conclusion: The aqueous extract of okra can markedly decline serum glucose and lipid in T2 DM rats.
- The aqueous extract of okra,
- SD rats,
- type 2 diabetes,
- blood glucose,
- serum lipids

FullText(HTML)

References(20)

References

[1]	Shaw J E,Sicree R A,Zimmet P Z.Global estimates of the prevalence of diabetes for 2010 and 2030[J].Diabetes Res Clin Pract,2010,87(1):4-14.
[2]	Pandey A,Tripathi P,Pandey R,et al.Alternative therapies useful in the management of diabetes:A systematic review[J].J Pharm Bioallied Sci,2011,3(4):504-512.
[3]	Sabitha V,Ramachandran S,Naveen K R,et al.Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus(L.)Moench.in streptozotocin-induced diabetic rats[J].J Pharm Bioallied Sci,2011,3(3):397-402.
[4]	Wang H,Chen G,Ren D,et al.Hypolipidemic activity of okra is mediated through inhibition of lipogenesis and upregulation of cholesterol degradation[J].Phytother Res,2014,28(2):268-273.
[5]	钟雨,闫明珠,张泽生,等.黄秋葵水提物抗运动疲劳作用研究[J].食品科技,2015(7):221-225.
[6]	Camciuc M,Deplagne M,Vilarem G,et al.Okra-Abelmoschus esculentus L.(Moench.)a crop with ecnomic potential for set aside acreage in France[J].Industrial Crops and products,1998,7:257-264.
[7]	邢冬杰,李广元,孙永庆,等.桑枝总黄酮提取物对2型糖尿病大鼠的作用研究[J].辽宁中医药大学学报,2010(7):57-58.
[8]	施新猷.现代医学实验动物学[M].北京:人民军医出版社,2000:333-335.
[9]	王晓琳,邱宗荫,夏永鹏.性别差异对实验性链脲佐菌素糖尿病大鼠造模的影响[J].第三军医大学学报,2009(17):1668-1671.
[10]	王嘉惠,沈小玲,符崇威,等.高脂喂养联合链脲佐菌素诱导大鼠2型糖尿病模型研究[J].吉林医学,2011(4):629-633.
[11]	Tomoda M,Shimizu N,Gonda R,et al.Anticomplementary and hypoglycemic activity of okra and hibiscus mucilages[J].Carbohydr Res,1989,190(2):323-328.
[12]	Fan S,Zhang Y,Sun Q,et al.Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice[J].The Journal of Nutritional Biochemistry.2014,25(7):702-709.
[13]	Taniguchi-Fukatsu A,Yamanaka-Okumura H,NaniwaKuroki Y,et al.Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity,lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance[J].Br J Nutr.2012,107(8):1184-1191.
[14]	孙元琳,汤坚.果胶类多糖的研究进展[J].食品与机械.2004(06):60-63.
[15]	王雪松,郑芸,方积年.降血糖多糖及寡糖的研究进展[J].药学学报.2004(12):1028-1033.
[16]	Jia W,Gao W,Tang L.Antidiabetic herbal drugs officially approved in China[J].Phytother Res.2003,17(10):1127-1134.
[17]	Woolfe J A.The effect of okra mucilage(Hibiscus esculentus L.)on the plasma cholesterol level in rats[J].Proc Nutr Soc.1977,36(2):59A.
[18]	Sabitha V,Ramachandran S,Naveen K R,et al.Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus(L.)Moench.in streptozotocin-induced diabetic rats[J].J Pharm Bioallied Sci.2011,3(3):397-402.
[19]	任丹丹,陈谷.黄秋葵多糖的提取、分离及其体外结合胆酸盐能力的分析[J].食品科学.2010(13):110-113.
[20]	王宏.黄秋葵降血脂的功能与作用机理研究[D].广州:华南理工大学,2013.