Research progress in preparation of chitooligosaccharide and its physiological activity

LIANG Hui- pei; QIN Xiao- li; ZHONG Jin- feng

doi:10.13386/j.issn1002-0306.2016.03.072

Article Contents

Article Navigation > Science and Technology of Food Industry > 2016 > (03): 384-388

LIANG Hui- pei, QIN Xiao- li, ZHONG Jin- feng. Research progress in preparation of chitooligosaccharide and its physiological activity[J]. Science and Technology of Food Industry, 2016, (03): 384-388. doi: 10.13386/j.issn1002-0306.2016.03.072

Citation:

LIANG Hui- pei, QIN Xiao- li, ZHONG Jin- feng. Research progress in preparation of chitooligosaccharide and its physiological activity[J]. Science and Technology of Food Industry, 2016, (03): 384-388. doi: 10.13386/j.issn1002-0306.2016.03.072

Citation:

PDF( 984 KB)

Research progress in preparation of chitooligosaccharide and its physiological activity

doi: 10.13386/j.issn1002-0306.2016.03.072

College of Food Sciences,Southwest University

Received Date: 2015-04-27

Abstract

Abstract

Chitooligosaccharide could be obtained by chemical and enzymatic hydrolysis of chitosan. It had good physical properties( low molecular weight,good solubility,high absorption and biocompatibility,etc.),and various physiological activities( immune function regulation,antitumous and antioxidative activities effects,etc.),which makes its promising use in the fields of food,medicine,etc.In this review,chitooligosaccharide preparation and its physiological activity were highly summarized,and the prospect of chitooligosaccharide was proposed.
- chitooligosaccharide,
- chitosan,
- preparation method,
- physiological activity

FullText(HTML)

References(51)

References

[1]	Dang Y,Li S,Wang W,et al.The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+)dendritic cells via toll-like receptor 4[J].Carbohydrate Polymers,2011,83(3):1075-1081.
[2]	Ma Y,Huang Q,Lv M Y,et al.Chitosan-Zn Chelate Increases Antioxidant Enzyme Activity and Improves Immune Function in Weaned Piglets[J].Biological Trace Element Research,2014,158(1):45-50.
[3]	Xu W,Jiang C,Kong X,et al.Chitooligosaccharides and Nacetyl-D-glucosamine stimulate peripheral blood mononuclear cell-mediated antitumor immune responses[J].Molecular Medicine Reports,2012,6(2):385-390.
[4]	Wu S J,Pan S K,Wang H B,et al.Preparation of chitooligosaccharides from cicada slough and their antibacterial activity[J].International Journal of Biological Macromolecules.2013,62:348-351.
[5]	Zhao D,Wang J,Tan L,et al.Synthesis of N-furoyl chitosan and chito-oligosaccharides and evaluation of their antioxidant activity in vitro[J].International Journal of Biological Macromolecules,2013,59:391-395.
[6]	陈奕兆,王亦佳,刚成诚,等.壳寡糖、PVP处理对冷藏水蜜桃的保鲜效果比较[J].食品科学,2013,34(18):332-336.
[7]	Balan V,Verestiuc L.Strategies to improve chitosan hemocompatibility:A review[J].European Polymer Journal,2014,53:171-188.
[8]	王鲁霞,马文平,朱辉,等.壳寡糖的性能及其在化妆品中的应用[J].科技创新与应用,2014,(27):16-17.
[9]	Niu J,Lin H Z,Jiang S G,et al.Comparison of effect of chitin,chitosan,chitosan oligosaccharide and N-acetyl-Dglucosamine on growth performance,antioxidant defenses and oxidative stress status of Penaeus monodon[J].Aquaculture,2013,372-375:1-8.
[10]	Liu H T,He J L,Li W M,et al.Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis[J].Carbohydrate Polymers,2010,80(4):1062-1071.
[11]	Li Y,Xu Q,Wei P,et al.Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling[J].International Journal of Molecular Medicine,2014,33(2):392-400.
[12]	李昱,王文霞,许青松,等.聚合度7-15的壳寡糖抑制脂多糖刺激的单核细胞产生TNF-α和IL-8的作用研究[J].天然产物研究与开发,2014,26(1):131-135.
[13]	Choi E H,Yang H P,Chun H S.Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation[J].Nutrition Research,2012,32(3):218-228.
[14]	Mourya V K,Inamdar N N,Choudhari Y M.Chitooligosaccharides:Synthesis,characterization and applications[J].Polymer Science Series A,2011,53(7):583-612.
[15]	刘琳,张杰,曾凡骏.过氧化氢法制备特定聚合度壳寡糖的工艺研究[J].食品科技,2011,36(3):88-91.
[16]	郑必胜,周萌.壳聚糖氧化降解制备壳寡糖的研究[J].现代食品科技,2012,28(8):959-963.
[17]	杨萍,徐贤柱,游清徽,等.内切壳聚糖酶在食品级壳寡糖酶法生产中的应用[J].食品科学,2011,32(13):169-172.
[18]	Wu S.Preparation of chitooligosaccharides from Clanis bilineata larvae skin and their antibacterial activity[J].International Journal of Biological Macromolecules,2012,51(5):1147-1150.
[19]	谭佩毅,黄秀锦.纤维素酶法制备壳寡糖工艺的研究[J].中国调味品,2012,37(12):79-83.
[20]	王亮,杨雨晗,吴东明,等.酶法制备壳寡糖及其生物学功能[J].生物加工过程,2010,08(3):28-34.
[21]	Xie H,Jia Z,Huang J,et al.Preparation of Low Molecular Weight Chitosan by Complex Enzymes Hydrolysis[J].International Journal of Chemistry,2011,3(2):180-186.
[22]	王振伟,申森.超声波辅助酶法制备壳寡糖及抗氧化活性研究[J].中国食品添加剂,2014,(4):70-75.
[23]	李恒,朱玉霞,苏建荣,等.微波-过氧化氢协同降黏辅助酶法制备壳寡糖[J].现代化工,2014,34(10):94-98.
[24]	何冰,张淑君,信志强,等.水力空化联合H2O2降解壳聚糖的研究[J].重庆理工大学学报(自然科学),2014,28(11):52-56.
[25]	Wu Y,Huang Y,Zhou Y,et al.Degradation of chitosan by swirling cavitation[J].Innovative Food Science and Emerging Technologies,2014,23:188-193.
[26]	Cai Q,Gu Z,Chen Y,et al.Degradation of chitosan by an electrochemical process[J].Carbohydrate Polymers.2010;79(3):783-785.
[27]	Cai Q,Gu Z,Fu T,et al.Kinetic study of chitosan degradation by an electrochemical process[J].Polymer Bulletin.2011;67(4):571-582.
[28]	Gu Z,Cai Q,Liu Y,et al.Electrochemical Degradation of Chitosan Using Ti/Sb-Sn O2Electrode[J].Journal of Polymers and the Environment.2013;21(2):479-486.
[29]	Wei X,Chen W,Mao F,et al.Effect of chitooligosaccharides on mice hematopoietic stem/progenitor cells[J].International Journal of Biological Macromolecules,2013,54:71-75.
[30]	Mei Y,Chen H,Zhang J,et al.Protective effect of chitooligosaccharides against cyclophosphamide-induced immunosuppression in mice[J].International Journal of Biological Macromolecules.2013,62:330-335.
[31]	张元,林强,宋玥.壳寡糖及其磷酸化修饰产物对小鼠脾淋巴细胞增殖及诱生细胞因子的影响[J].食品科技,2012,37(2):11-15.
[32]	Kim E K,Je J Y,Lee S J,et al.Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells[J].Bioorganic&Medicinal Chemistry Letters,2012,22(19):6136-6138.
[33]	罗福文,万莹,张翠丽,等.壳寡糖对肝癌细胞SMMC-7721中Bcl-2和Caspase-3表达的影响[J].中国微生态学杂志,2009,21(10):906-909.
[34]	Li X,Wang J,Chen X,et al.Effect of chitooligosaccharides on cyclin D1,bcl-xl and bcl-2 mRNA expression in A549 cells using quantitative PCR[J].Chinese Science Bulletin,2011,56(15):1629-1632.
[35]	Wang K,Zhang T,Liu L,et al.Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells[J].International Journal of Nanomedicine.2012,7:4487-4497.
[36]	金黎明,郝苗,赵小菁,等.硒化壳寡糖的合成及抗氧化作用研究[J].大连民族学院学报,2012,14(5):445-448.
[37]	郭芳宁,李春超,金黎明,等.壳寡糖铁配合物的合成及抗氧化作用[J].食品工业科技,2013,34(20):119-121.
[38]	Ngo D H,Qian Z J,Vo T S,et al.Antioxidant activity of gallate-chitooligosaccharides in mouse macrophage RAW264.7cells[J].Carbohydrate Polymers,2011,84(4):1282-1288.
[39]	Qiao Y,Bai X F,Du Y G.Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress[J].International Immunopharmacology,2010,11(1):121-127.
[40]	付红岩,姚晶,金惠玉,等.壳寡糖功能性绿茶酸奶的研制[J].食品工业科技,2013,34(14):220-223.
[41]	汪连生,彭惠娥,李伟,等.壳寡糖影响亚硒酸钠对微生物生长的作用[J].食品科学,2010,31(7):196-198.
[42]	Wu S.Preparation of chitooligosaccharides from Clanis bilineata larvae skin and their antibacterial activity[J].International Journal of Biological Macromolecules,2012,51(5):1147-1150.
[43]	KoppováI,BureM,imunek J.Intestinal bacterial population of healthy rats during the administration of chitosan and chitooligosaccharides[J].Folia Microbiologica,2012,57(4):295-299.
[44]	Karadeniz F,Artan M,Kong C S,et al.Chitooligosaccharides protect pancreaticβ-cells from hydrogen peroxide-induced deterioration[J].Carbohydrate Polymers,2010,82(1):143-147.
[45]	刘冰,秦贞奎,林祥梅,等.壳寡糖及其配合物对胰岛细胞增殖、胰岛素分泌的促进作用[J].中国组织工程研究与临床康复,2009,13(3):513-516.
[46]	Zhang C M,Yu S H,Zhang L S,et al.Effects of several acetylated chitooligosaccharides on antioxidation,antiglycation and NO generation in erythrocyte[J].Bioorganic&Medicinal Chemistry Letters,2014,24(16):4053-4057.
[47]	汪茂荣,姚平,张波,等.甲壳低聚糖对链脲佐菌素致糖尿病小鼠血糖与肠道菌群的影响[J].中国生化药物杂志,2014,34(9):72-74.
[48]	Choi C R,Kim E K,Kim Y S,et al.Chitooligosaccharides decreases plasma lipid levels in healthy men[J].International Journal of Food Sciences and Nutrition,2012,63(1):103-106.
[49]	He B,Wang J.Chitooligosaccharides prevent osteopenia by promoting bone formation and suppressing bone resorption in ovariectomised rats:possible involvement of COX-2[J].Natural Product Research,2015,29(4):359-362.
[50]	刘宇桐,金黎明,徐鑫,等.硒化壳寡糖对成骨细胞的作用[J].安徽农业科学,2012,40(26):12778-12779.
[51]	张姣,戴雪伶,姜招峰,等.生物活性物质壳寡糖对阿尔茨海默病防治作用研究进展[J].食品科学,2013,34(11):316-320.