Abstract: The total saponins were examined in the dissepiment of Wu walnut. On the basis of single factor experiments with the method of ultrasonic-assisted extraction,optimal parameters of extraction process was researched by using response surface method. A mathematical model including material/liquid ratio,ultrasonic treatment time and extraction temperature was created. By typicality analysis,the optimum process conditions were as follows:the ultrasonic treatment time was 96 s,the ultrasonic power was 300 W and the material/liquid ratio was 1∶33(g/m L). Under such conditions,an optimal total saponins yield of 5.98% was obtained. Saponins displayed strong antioxidant effect and scavenging capacity against DPPH,ABTS radical,and more strengthen with the increase in the concentration of total crude saponins extract.