Abstract: Interaction between polysaccharides and phenolics has significant influence on structure, the synergies after mixing of polysaccharides and phenolics can construct new functional which are agents capable of changing and improving functional characteristics in the biological medicine, health food and cosmetics. In this paper, the recent researches from the aspect of interaction from the change of the structure to functional activity of polysaccharides, phenolics and their the practical application were reviewed.