Abstract: To explore the protection of Lonicera caerulea ‘Beilei ' anthocyanins on ethanol induced oxidative injury in mice. According to the weight, mice were randomly divided into 6 groups, the control group, model group, VCcontrol group ( 20 mg/kg BW) , anthocyanins low dose group ( 50 mg/kg BW) , anthocyanin medium dose group ( 100 mg/kg BW) and anthocyanin high dose group ( 200 mg/kg BW) .The volume of oral gavage was 0.2 m L/10 g per day, and the control group and model group were filled with normal saline.After 30 days, the oxidative damage model was induced by oral gavage with ethanol except the control group. The content of malondialdehyde ( MDA) , protein carbonyl ( PC) , superoxide dismutase ( SOD) , glutathione peroxidase ( GSH-PX) and glutathione ( GSH) in blood and tissues were detected. Results showed that Lonicera caerulea ‘Beilei ' anthocyanins could significantly reduce the content of MDA and PC in mice ( p < 0.01) , and it could significantly ( p < 0.01) improve the activity of SOD and GSH-PX in vivo and raise the content of GSH. Lonicera caerulea‘Beilei'anthocyanins have protective effect in preventing oxidative damage in mice.