Abstract: In order to investigate the mechanism of bvine collagen oligopeptide(BCOPs)promoting wound healing in mice after skin incision surgery. A total of 96 SPF ICR male mice were randomly divided into control group and 3 BCOPs intervention groups(0.375,0.75,1.5 g/kg·bw,respectively),and 24 mice in each group. The mice were carried out by mice stomach-lavaging continuously for 11 d after incision wound model. 8 mice each group were sacrificed separately at 3rd d,7th d,and 11th d. It was found that the tension strength of mice in the high-dose BCOPs group was significantly higher than that in control group at day 11.Low,medium and high dose BCOPs could significantly increase the concentrations of ALB and PA in serum at 3rd d,7th d,and 11th d(p<0.05). The medium and high dose BCOPs could markedly promote the expression levels of IL-10 in serum at day 3,7 and 11(p<0.05),while BCOPs could also significantly inhibit the expression levels of TNF-α(p<0.05). Therefore,BCOPs can effectively promote the wound healing in mice,which may be related to improving the nutritional status and inhibiting the inflammatory response in mice.