Abstract: Objective:To establish a rapid screening method for the 22 illegally added chemical drugs by ion mobility spectrometry (IMS) in weight-loss health foods. Methods:After ultrasonic extraction of the sample with appropriate amount of 80% methanolsolution to obtain the sample reserve solution, the sample reserve solution was diluted with 80% methanolsolution containing 0.5% acetic acid (V/V), and the positive ion mode (source voltage of 2200 V) was employed to detect probucol, fluoxetine hydrochloride, bupropion hydrochloride, pioglitazone hydrochloride, repaglinide, gemfibrozil, sibutramine hydrochloride, N-desmethylsibutramine hydrochloride, N, N-didesmethylsibutramine hydrochloride, fluoxetine hydrochloride, rosiglitazone maleate, pseudoephedrine hydrochloride, methamphetamine hydrochloride, fenofibrate, indapamide, bisacodyl, metformin hydrochloride and phenolphthalein. The sample reserve solution was diluted with 80% methanolsolution containing 0.5% ammonia water (V/V), and the negative ion mode (source voltage of 1800 V) was employed to detect furosemide, hydrochlorothiazide, chlorothiazide and fluvastatin sodium. The drift tube voltage was 8000 V, the gas inlet and drift tube were both controlled at the temperature of 180℃.The gate voltage was 45 V and the gate pulse width was 120 μs. 40 batches of weight-loss health foods were detected by the established method. Results:This method had good specificity. The drift time of all 22 kinds of weight-loss drugs were between 8.0 and 16.3 ms, and their detection limits were 0.05~8.0 mg·L^-1 in the matrix. Sibutramine was detected in 1 batch, phenolphthalein was detected in 1 batch, and fluoxetine was detected in 1 batch. Conclusion:The established method is rapid and sensitive, which is suitable for the rapid screening of the illegal addition of chemicals in weight-loss health foods.