Abstract: In order to develop a meal replacement powder suitable for obese people,a fat microcapsule was prepared by spray drying. Through the design of three energy-supplying nutrient ratios,a formula for meal replacement powder was obtained. The high-speed granulation process was used to improve the solubility of meal replacement powder. The glycemic index(GI)test was performed on meal replacement powder to evaluate the effect on blood sugar after consuming meal replacement powder. The results showed that the surface of the fat microcapsule particles was intact and dense. In addition,adding micro-capsules of composite antioxidant tea polyphenol palmitate(TP)and 0.15% of L-ascorbyl palmitate(L-AP)could further slow down the rise of oil peroxidation during storage and improve the oxidation stability of the oil. Secondly,after high-speed granulation,the fluidity of the meal replacement powder was significantly improved,and the fluidity index increased from 59.0 to 77.5. The particle size of the powder after granulation was mainly distributed around 600 μm,and it had a certain fast solubility,and the scattered light intensity of meal replacement powder after granulation was obviously higher than that before granulation. Finally,the GI value of the meal replacement powder was measured by human body,and the GI value was 52.2±5.1. After consumption,it can play a role in stabilizing blood sugar,which is suitable for people with abnormal glucose metabolism.