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中国精品科技期刊2020
胡付侠,初侨,白若熙,等. 辣椒生物碱的活性与利用度改进技术研究进展[J]. 食品工业科技,2021,42(15):412−419. doi: 10.13386/j.issn1002-0306.2020070406.
引用本文: 胡付侠,初侨,白若熙,等. 辣椒生物碱的活性与利用度改进技术研究进展[J]. 食品工业科技,2021,42(15):412−419. doi: 10.13386/j.issn1002-0306.2020070406.
HU Fuxia, CHU Qiao, BAI Ruoxi, et al. Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids[J]. Science and Technology of Food Industry, 2021, 42(15): 412−419. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070406.
Citation: HU Fuxia, CHU Qiao, BAI Ruoxi, et al. Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids[J]. Science and Technology of Food Industry, 2021, 42(15): 412−419. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070406.

辣椒生物碱的活性与利用度改进技术研究进展

Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids

  • 摘要: 辣椒生物碱是辣椒辛辣的物质基础和主要的生物活性成分,具有抗癌、抗炎、抑菌、缓解疼痛、减肥、抗氧化、保护胃肠道等多种功效,但因其刺激性大、溶解度差、稳定性差和肝首过效应等问题使其生物利用度较低。本文系统地总结了近年来关于辣椒生物碱生物学活性的作用机理,以及脂质体、微球、微乳、羟丙基-β-环糊精与前药自组装技术等提高其生物利用度的研究进展,为辣椒生物碱的利用提供理论依据及技术支持。

     

    Abstract: Capsicum alkaloids, with various biological activities such as anti-cancer, anti-inflammatory, antibacterial, relieving pain, weight loss, anti-oxidation, protect the gastrointestinal tract, are the material basis and the main biologically active ingredients of capscium. However, the high stimulation, poor solubility, poor stability, liver first pass effect and other problems make its bioavailability low. In this review, recent advances in the mechanism of the versatile bioactivities of capsicum alkaloids and in the development of technologies for enhancing capsicum alkaloids bioavailability such as the use of liposome, microsphere, emulsion, hydroxypropyl -β- cyclodextrin, prodrug self-assembly technology are systematically summarized. It provides theoretical basis and technical support for the application of capsicum alkaloids in the future.

     

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