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中国精品科技期刊2020
贾宏信,苏米亚,陈文亮,等. 鱼油补充对中老年人群炎性衰老及相关疾病有益作用的研究进展[J]. 食品工业科技,2021,42(19):443−450. doi: 10.13386/j.issn1002-0306.2020090064.
引用本文: 贾宏信,苏米亚,陈文亮,等. 鱼油补充对中老年人群炎性衰老及相关疾病有益作用的研究进展[J]. 食品工业科技,2021,42(19):443−450. doi: 10.13386/j.issn1002-0306.2020090064.
JIA Hongxin, SU Miya, CHEN Wenliang, et al. Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population[J]. Science and Technology of Food Industry, 2021, 42(19): 443−450. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090064.
Citation: JIA Hongxin, SU Miya, CHEN Wenliang, et al. Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population[J]. Science and Technology of Food Industry, 2021, 42(19): 443−450. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090064.

鱼油补充对中老年人群炎性衰老及相关疾病有益作用的研究进展

Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population

  • 摘要: 鱼油富含n-3多不饱和脂肪酸(n-3 polyunsaturated fatty acids, n-3 PUFA),特别是人体必需脂肪酸二十二碳六烯酸(docosahexaenoic acid, DHA)和二十碳五烯酸(eicosapentaenoic acid, EPA)。DHA和EPA在体内可以衍生出具有抗炎作用的二十碳体,如前列腺素(prostaglandins, PGs)、血栓素(thromboxanes, TX)、消退素(resolvins, Rv)、白三烯(leukotrienes, LTs)和其他氧化衍生物等。且鱼油补充有助于人体炎性衰老相关因子(血清 IL-6、IL-1、TNF-α及 CRP)水平的降低,并对炎性衰老相关疾病具有积极预防效果。本文系统介绍了DHA、EPA二十碳体的衍生及与二十碳四烯酸(arachidonic acid, AA)衍生的关系。同时基于鱼油补充与人体炎性衰老相关因子的关系,总结了膳食鱼油在改善中老年人群心血管疾病、类风湿关节炎、认知障碍及2型糖尿病的作用。已有数据显示,鱼油在降低炎性衰老因子,血脂异常改善和类风湿性关节炎症状减轻方面具有积极的临床效果。但是,在认知功能障碍和2型糖尿病改善方面,尚缺乏充分的治疗或者预防作用相关证据。

     

    Abstract: Fish oil is rich in n-3 polyunsaturated fatty acids (n-3 PUFA), especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA and EPA can produce eicosanoids with anti-inflammatory properties in the body, such as prostaglandins (PGs), thromboxanes (TX), resolvins (RV), leukotrienes (LTs) and other oxidative derivatives. Moreover, fish oil supplementation can reduce the levels of inflammatory aging related factors (serum IL-6, IL-1, TNF-α and CRP), and has positive preventive effect on inflammatory aging related diseases.In this paper, the icosahedron derivation of DHA and EPA and their relationship with the derivatization of arachidonic acid (AA) are introduced. Meanwhile, based on the relationship between fish oil supplement and inflammatory aging related factors, the effects of dietary fish oil on cardiovascular disease, rheumatoid arthritis, cognitive impairment and type 2 diabetes mellitus in middle-aged and elderly people were summarized. Data have shown that fish oil has a positive clinical effect in reducing inflammatory aging factors, improving dyslipidemia and reducing the symptoms of rheumatoid arthritis.However, there is insufficient evidence of a therapeutic or preventive effect on cognitive impairment and type 2 diabetes.

     

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