Abstract: Chitosan, a natural and safe polymer, has antibacterial, metal chelating, clarifying and antioxidant effects in the fruit wine making industries. However, the activity strength and action mechanism of chitosan in the brewing process is still unclear. In this review, the action mode of chitosan and its derivatives as antibacterial, antioxidant and clarifying agent, their application status in fruit wine brewing are summarized, the development bottleneck problems are analyzed, as well as their potential application value is discussed, attempting to promote the further research, development and utilization of chitosan and its derivatives in fruit wine and boost the development of fruit wine industry.