Protective effect of Lingonberry extraction on chronic stressed mice

In order to study the protective effect of Lingonberry extraction on chronic stressed mice,total 60 male Kunming mice were randomly divided into 6 groups :normal control group,stressed model group,positive group( Fluoxetine 4. 4 mg / kg·d), experience group( low, medium, high dose were 50, 100, 200 mg / kg·d respectively). Use the chronic stress animal model to research anti stress effect of Lingonberry in behavior and physiology. Compared with control group,model mice immobility duration significantly prolonged in tail suspended test(p<0.05),cerebral SOD,GSH-Px and 5-HT decreased(p<0.05),MDA increased(p<0.05),serum NE and 5-HT decreased(p <0.05),GC and ACh E increased(p <0.01,p <0.05 respectively). Compared with model group,the mice of high dose group immobility duration significantly shortened in tail suspended test,low dose group mice cerebral MDA reduced(p<0.05),high dose mice cerebral SOD,high and low dose group mice cerebral 5-HT,and low dose group cerebral tissue GSH-Px content increased(p<0.05). High dose group serum GC and ACh E decreased(p <0.01,p <0.05),middle dose group serum 5-HT increased(p <0.05). In conclusion,Lingonberry can greatly protect the body,reduce the adverse effects of chronic stress on mice.