Research Progress on the Pharmacokinetics of Acanthopanax senticosus Harms Chemical Constituents and Its Metabolism in Vivo

Acanthopanax senticosus(AS)is one of the major medicinal varieties in Jilin province. The classical application of AS is nourishing qi and strengthening the spleen,nourishing the kidney and soothing the nerves. It has significant anti-fatigue effect in clinic. The main chemical components of AS are glycosides,flavones,coumarins,polysaccharides,lignans and so on. The diversity of chemical constituents of AS also leads to the complexity of its pharmacokinetics. The recent advances in pharmacokinetics characteristics,absorption,distribution and metabolism of chemical compounds of AS are analysised. Metabolic process of chemical compounds from AS in vivo are deeply excavated and explored,which provides a reference for the development and utilization of bioactive substances of AS.