Protection Effect of Anthocyanins from the Chinese Dwarf Cherry ‘Nongda No 4’ on Aging Mouse by D-galactose

In order to study the effect of anthocyanin from the Chinese dwarf cherry ‘Nongda No 4’ on the protection of aging mouse,a mouse model of aging was established by subcutaneously injecting D-galactose in the neck and back,and the aging mice were gavaged with different doses(500,250,125 mg·(kg·d)^-1)of anthocyanins. The heart,liver,spleen,lung and kidney indexes and the contents of malondialdehyde(MDA)and the activities of total antioxidant capacity(T-AOC),catalase(CAT),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)in the heart,liver,spleen,kidney and serum of mice were assessed. The results showed that compared with the control group,the liver,spleen and kidney indexes of mice in the model group decreased significantly(P<0.05),T-AOC,SOD,GSH-Px,and CAT activities in the serum and organs decreased significantly(P<0.05),and MDA content increased significantly(P<0.05),indicating successful construction of aging mice model. Compared with the model group,the liver,spleen and kidney indexes and T-AOC,SOD,GSH-Px,and CAT activities in the serum and organ tissues were increased significantly(P<0.05)and MDA content was decreased significantly(P<0.05)of mice in the high dose. Therefore,anthocyanins from the Chinese dwarf cherry ‘Nongda No 4’ can effectively improve the antioxidant ability and protection ability in mice.