Abstract: To study the effect of jujube polysaccharide (JP) on blood glucose and glucose tolerance of the normal mice.The results showed that JP had no effect on blood glucose of the normal mice, but improved their glucose tolerance.To study the influence of JP on blood glucose and blood insulin of the diabetic mice, alloxan diabetic mice models and adrenaline hyperglycemic mice models were constructed by administering alloxan (200mg/kg) and adrenaline (0.03mg/kg) to the mice through intraperitoneal injection, respectively.The diabetic mice were randomly divided into five groups, including model control, JP large dose (0.8g/kg) , JP middle dose (0.4g/kg) , JP low dose (0.2g/kg) and positive control group, all the experimental samples were administrated through gastry lavage.The normal control group was setted up at the same time and given equal volume water.The fasting blood glucose and blood insulin of the mice were analyzed 14d later.The result showed that JP had no significant effect on the mice blood glucose quickly risen by adrenaline.However, JP at the dose of 0.8g/kg significantly reduced the blood glucose and increased the blood insulin level of the alloxan diabetic mice.