白背三七对小鼠胃肠蠕动功能的影响
Effect of gynura divaricata on the function of gastrointestinal motility in mice
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摘要: 目的:观察白背三七对小鼠胃肠蠕动功能的影响。方法:在体观察白背三七对正常小鼠和阿托品致便秘模型小鼠胃排空率和小肠碳末推进率的影响;离体观察白背三七对正常离体小肠和阿托品抑制离体小肠收缩频率和收缩张力的影响。结果:白背三七能提高正常小鼠胃排空率和小肠碳末推进率,与正常对照组比较具有显著性差异(p<0.01或p<0.05);能提高阿托品致便秘小鼠胃排空率和小肠碳末推进率,与阿托品组比较具有显著性差异(p<0.01或p<0.05);能提高正常小鼠离体小肠收缩频率和收缩张力,与正常对照组比较具有显著性差异(p<0.01或p<0.05);能提高阿托品抑制离体小肠收缩频率和收缩张力,与阿托品组比较具有显著性差异(p<0.01或p<0.05)。结论:白背三七能增强小鼠胃肠蠕动功能。Abstract: Objective:To observe the effect of gynura divaricata on the function of gastrointestinal motility in mice.Methods:Effect of gynura divaricata on the rate of gastric emptying and small intestine facilitation in normal mice and constipation mice induced by atropine in vivo were observed, and contraction frequency and contraction tension in normal small intestine and inhibition small intestine by atropine in vitro were also observed.Result:Gynura divaricata could elevate the rate of gastric emptying and small intestine facilitation in normal mice comparing with normal mice ( p < 0.01 or p < 0.05) , gynura divaricata could also elevate the rate of gastric emptying and small intestine facilitation in constipation mice induced by atropine comparing with model mice ( p < 0.01 or p < 0.05) . Gynura divaricata could increase contraction frequency and contraction tension in normal small intestine in vitro comparing with normal small intestine ( p < 0.01 or p < 0.05) , gynura divaricata could also increase contraction frequency and contraction tension in inhibition small intestine by atropine in vitro comparing with inhibition small intestine by atropine ( p < 0.01 or p < 0.05 ) .Conclusion:Gynura divaricata could improve the function of gastrointestinal motility in mice.
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