Abstract: Soy-based infant formula is a kind of powdery food which is on the base of soy protein and developed to satisfied nutrient requirement of infant.As a supplement for milk, soy-based infant formulas can ease the deficiency of breast feeding, high price burden of milk powder, milk allergy of some infants and some other problems. Soy-based formula has a history of more than eighty years. More and more people take it as a choice in some countries and districts. Its development attracts increasing attention and the manufacturing process is gradually optimizing.However, there are also some problems such as anti- nutritional factors and bad solubility which affect the value of nutrition and safety. The process technology progress of soy-based infant formula from the development, as well as nutritional and safety issues were reviewed in this passage.