Abstract: The antioxidant activities in vitro of fermentation products from Fomitopsis pinicola were investigated by scavenging DPPH, hydroxyl radical experiments and a protection test model of oxidative damage to yeast cells.The results indicated that both Fomitopsis pinicola fermentation concentrates and ethanol sediments had significant effects on scavenging radicals and oxidative damages, even could compare with the activity of nature antioxidant BHT.Moreover, their scavenging abilities were positively correlated with the dose. The effective concentrations of FPC and FPES that scavenged 50% ( EC50) DPPH were 7.69 and 7.72mg/mL, respectively, while that value were4.42 and 4.44mg /mL on hydroxyl, 30.40mg /mL and 34.87mg /mL on UV oxidative damage, 27.12 and 30.61mg /mL on H2O2oxidative damage, respectively. So it can be concluded that the fermentation products of Fomitopsis pinicola showed significant antioxidant activity.