Abstract: The aim of this study was to point out the effect of buckwheat on antioxidant activity of hyperlipidemia rats. Fifty male Wistar hamsters were assigned randomly to the following groups:control diet,high-fat diet(HFD)and low,medium,high dosage BW(1,5,10g/kg·d) groups. The SOD,GSH-PX and MDA in serum and SOD,MDA in livers were detected after 30 days. The results showed that compared with model group,the levels of SOD,GSH-PX were increased(p<0.05),MDA was decreased(p<0.05) in serum,the buckwheat group SOD was increased(p<0.05),MDA was decreased(p<0.05) in liver of buckwheat group. Buckwheat may improve the antioxidant activity of high-fat diet-induced rats.