Abstract: Objective: To study the effects of grape seed powder on parameters of hemorheology and antioxidant function in high- diet rats. Methods: Sixty male Wistar rats were divided into five groups,including control group,high- fat diet group and grape seed powder low-,medium- and high- dose groups.The control group was fed with basic diet,and other groups were fed with high fat / cholesterol diet during the experiment.The doses of grape seed power in low-,midium- and high- dose groups treated with 0.33 g / kg·bw,1.67 g / kg·bw,3.33 g / kg·bw of grape seed powder. After administration,parameters of hemorheology,activities of SOD and content of MDA in serum were measured.Results: Compared with the high- fat diet group,grape seed powder could reduce the ηb,ηp,HCT,IER and IEA,increase IED,increase the activities of SOD,and reduce the content of MDA in high- fat diet rats.Conclusion: Grape seed powder could improve parameters of hemorheology,reduce blood viscostities,inhibit lipid peroxidation and prevent arteriosclerosis.