Abstract: Coffee pulp was used as material.Orthogonal test and response surface as an approach were to optimize the conditions of pretreatment and fermentation process.The results showed that: the optimum pretreatment conditions were as follows: additive amount of cellulase as 1%, enzymolysis temperature of 35 ℃, hydrolysis time of 3 h, and the content of soluble solids change the most of 1.7%.The optimized fermentation conditions were as follows: inoculums size of yeast 7.5%, the sugar degree of fermentation 22%, fermentation temperature 29 ℃, and the fermentation time for 7 d as well as the alcohol content about10.8%.The coffee pulp fruit wine possessed amber, rich coffee flavor and clarity.The content of caffeine was 34.3 mg/L.