Abstract: Objective:To study the effect of luteolin on hepatic steatosis and antioxidation in hyperlipidemia rats. Methods:Forty SD rats were randomly divided into normal group,model group,luteolin group and simvastatin group. High-fat diets were fed to establish hyperlipidemia rat model and then given by gastrogavage. Body weight were measured weekly,liver wet weight were measured after 6 weeks,serum TC,TG,HDL,LDL were detected. Antioxidant indicators of liver tissue such as SOD,GSH-Px,MDA,CAT of liver tissue were detected,the degree of steatosis was observed by pathological section and histological score. Results:Compared with the normal group,the body weight,liver weight and liver index of the model control group significantly increased(p<0.01),and TC,TG,LDL-C and HDL-C levels of serum significantly increased(p<0.05),obvious fatty degeneration occurred,MDA content increased significantly(p<0.01),CAT content decreased significantly(p<0.05). Compared with the model control group,the body weight and liver index of the luteolin group and the simvastatin group significantly decreased(p<0.01),and TC,TG,LDL-C levels of serum were significantly decreased(p<0.01,p<0.01,p<0.05). The fatty deposition of liver cells could also be alleviated,the MDA content significantly decreased(p<0.01),and the CAT content significantly increased(p<0.05,p<0.01).Conclusion:Luteolin could significantly reduce liver steatosis,which might be achieved by reducing blood lipid levels in SD rats and combating oxidative stress.