Abstract: Object:To study the antioxidant activity and anti-aging effect of summer black grape anthocyanin extract. Methods:The antioxidant activity of summer black grape anthocyanin extract was studied by measuring the ability to scavenge 1,1-diphenyl-2-trinitrophenylhydrazine(DPPH)free radicals,superoxide anion,hydroxyl radicals,and total reducing power.40 aging model mice,which were established by injecting D-galactose into the nape of the neck,were fed with different doses of summer black grape anthocyanin for 30 days,and blood samples were taken after 24 h of fasting to detect the levels of superoxide dismutase(SOD)andmalondialdehyde(MDA)in serum. Brain and kidney were taken for hematoxylin-eosinstaining(HE)pathological tissue sections to observe the histopathological changes. Results:Summer black grape anthocyanin had strong scavenging ability against DPPH radicals,superoxide anion,and hydroxyl radicals. Compared with the model group,SOD level in serum of mice was lower than that of medium and high dose groups(P<0.05),while medium and high dose group was higher than that of low dose groups(P<0.05),and significantly reduce the level of serum MDA(P<0.05).From the histopathological sections of brain and kidney,with the increase of anthocyanin dosage,the morphology of neurons gradually became regular and abundant,the cell gap became smaller,the number of cells were larger,arranged neatly,the number of glomeruli was increased and abundant,and the morphology became plump. Conclusion:Summer black grape anthocyanin extract has certain antioxidant ability,and it has a better protective effect on D-galactose aging mice.