益生菌活性代谢产物的研究及应用进展

兰冬雪; 瞿茜楠; 黄天; 姚国强; 扎木苏; 彭传涛; 李兆杰

doi:10.13386/j.issn1002-0306.2022050305

益生菌活性代谢产物的研究及应用进展

doi: 10.13386/j.issn1002-0306.2022050305

兰冬雪^{1, 2, 3,},
瞿茜楠^{1, 2, 3},
黄天³,
姚国强³,
扎木苏³,
彭传涛^{1, 2},
李兆杰^{1, 2, 3, ,}

1.
青岛农业大学食品科学与工程学院，山东青岛 266109
2.
青岛特种食品研究院，山东青岛 266109
3.
内蒙古农业大学乳品生物技术与工程教育部重点实验室，内蒙古呼和浩特 010018

基金项目: 山东省自然科学基金面上项目（ZR2020MC217）。

详细信息

作者简介:
兰冬雪（1997−），女，硕士研究生，研究方向：益生菌活性代谢产物研究，E-mail：1744904516@qq.com

通讯作者:
李兆杰（1981−），男，博士，教授，研究方向：益生菌筛选及功效评价，E-mail：hunterlee_81@163.com

中图分类号: TS252.1
计量
- 文章访问数: 132
- HTML全文浏览量: 170
- PDF下载量: 66
- 被引次数: 0
出版历程
- 收稿日期: 2022-05-26
- 网络出版日期: 2022-11-17
- 刊出日期: 2022-12-15

Research and Application Progress of the Active Metabolites of Probiotics

LAN Dongxue^{1, 2, 3
,},
QU Xinan^{1, 2, 3},
HUANG Tian³,
YAO Guoqiang³,
ZHA Musu³,
PENG Chuantao^{1, 2},
LI Zhaojie^{1, 2, 3
, ,}

1.
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
2.
Qingdao Special Food Research Institute, Qingdao 266109, China
3.
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Huhhot 010018, China

摘要

摘要: 益生菌因对机体具有多种益生功效而逐渐成为研究热点。益生菌的多种益生特性与其代谢产生的活性产物密切相关。益生菌的活性代谢产物主要有胞外多糖、细菌素、维生素、有机酸和短链脂肪酸等，它们在抗炎症、抗氧化、调节免疫、预防或治疗代谢性疾病等方面发挥积极作用，很多已被用于医疗、食品防腐、畜牧养殖等多个行业中。尽管益生菌活性代谢产物有较好的益生功能和应用潜力，但在提高产量、降低生产纯化成本、探明作用机制等方面仍需进行深入探索。本文主要对益生菌活性代谢产物的种类、功能及其应用等方面进行综述，为其在食品、医疗、保健、畜牧等领域的研究应用提供更多参考。
- 益生菌 /
- 代谢产物 /
- 胞外多糖 /
- 细菌素 /
- 短链脂肪酸 /
- 有机酸 /
- 功能
Abstract: Probiotics is an intriguing research focus due to its multiple beneficial effects on host, which is closely associated with its bioactive metabolites, including extracellular polysaccharides, bacteriocins, vitamins, organic acids and short-chain fatty acids. They are widely used in medical treatment, food antiseptic, animal husbandry and other industrial areas for their broad beneficial effects, such as anti-inflammation, anti-oxidation, immune regulation and preventive and therapeutic properties against metabolic diseases. Even though the functionalities and application potential of probiotics are extensively studied, further efforts are needed to focus on the increase of their productivity, reducing the cost of production and purification and exploring the cellular and molecular mechanisms. Here we review the category, functions and applications of probiotic metabolites, and would provide more insights for their utilizations in food, medicine, health care and animal husbandry.
- probiotics /
- metabolites /
- extracellular polysaccharides /
- bacteriocins /
- short chain fatty acids /
- organic acids /
- function

HTML全文

图 1 益生菌活性代谢产物、功能及应用

Figure 1. Active metabolites of probiotics，functions and applications

下载: 全尺寸图片幻灯片

表 1 益生菌产胞外多糖的菌株及功能

Table 1. Strains and functions of probiotics producing extracellular polysaccharides

功能	菌株	参考文献
抗氧化活性	Lactobacillus sp. Ca6	[11−13]
	Lactobacillus plantarum HY
抗肿瘤作用	Lactobacillus kefiri MSR101	[14−16]
	Lactobacillus delbureckii
	Lactobacillus plantarum 70810
免疫调节作用	Lactobacillus rhamnosus KF5	[17−19]
	Lactobacillus helveticus LZ-R-5
	Lactobacillus planetarium JLAU103
抗炎作用	Lactobacillus planetarium	[20−24]
	Lactobacillus reuteri Mh-001
	Lactobacillus casei WXD030
	Lactobacillus paraplantarum BGCG11
	Bacillus licheniformis
	Leuconostoc mesenteroides
抗生物膜作用	Lactobacillus fermentum LB-69	[25−27]
	Lactobacillus fermentum S1
	Lactobacillus plantarum（EPLB）

下载: 导出CSV

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