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中国精品科技期刊2020
严静,薛秋艳,王旸,等. 发酵米荞对高脂肪秀丽隐杆线虫的降脂及抗氧化作用[J]. 食品工业科技,2023,44(6):8−15. doi: 10.13386/j.issn1002-0306.2022070044.
引用本文: 严静,薛秋艳,王旸,等. 发酵米荞对高脂肪秀丽隐杆线虫的降脂及抗氧化作用[J]. 食品工业科技,2023,44(6):8−15. doi: 10.13386/j.issn1002-0306.2022070044.
YAN Jing, XUE Qiuyan, WANG Yang, et al. Hypolipidemic and Antioxidant Effects of Fermented Rice Buckwheat on High-fat Caenorhabditis elegans[J]. Science and Technology of Food Industry, 2023, 44(6): 8−15. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070044.
Citation: YAN Jing, XUE Qiuyan, WANG Yang, et al. Hypolipidemic and Antioxidant Effects of Fermented Rice Buckwheat on High-fat Caenorhabditis elegans[J]. Science and Technology of Food Industry, 2023, 44(6): 8−15. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070044.

发酵米荞对高脂肪秀丽隐杆线虫的降脂及抗氧化作用

Hypolipidemic and Antioxidant Effects of Fermented Rice Buckwheat on High-fat Caenorhabditis elegans

  • 摘要: 本文旨在研究发酵米荞的降脂及抗氧化作用。以高糖(10 mmol/L)诱导建立秀丽隐杆线虫高脂肪模型,经发酵米荞干预后,测定其对高脂肪线虫寿命、运动能力、产卵量、活性氧(ROS)水平、抵抗氧化应激能力和抗氧化酶活力的影响;同时,检测了其对高脂肪线虫体内甘油三脂和游离脂肪酸含量的影响。结果表明,经发酵米荞干预的高脂肪线虫的最大寿命极显著增加30.90%(P<0.01),运动能力极显著提升28.57%(P<0.01),产卵量增加(P>0.05);同时,发酵米荞可以极显著提高高脂肪线虫体内抗氧化酶活性(P<0.01)、降低丙二醛含量及ROS水平(P<0.01),并且极显著提升其抵抗氧化应激能力(P<0.01)。此外,发酵米荞还能极显著降低高脂肪线虫的甘油三酯及游离脂肪酸含量,分别降低了56.58%和130.54%(P<0.01)。综上所述,发酵米荞可通过增强抵抗氧化应激能力、减少脂肪沉积和提高抗氧化酶活性发挥其对高脂肪线虫的降脂作用。

     

    Abstract: This research aimed to investigate the hypolipidemic and antioxidant effects of fermented rice buckwheat. A high-fat model of Caenorhabditis elegans (C. elegans) was established by high sugar (10 mmol/L) induction. After the treatment of fermented rice buckwheat, its effects on the longevity, motility, egg production, reactive oxygen species (ROS) levels, resistance to oxidative stress, and antioxidant enzyme activity of high-fat C. elegans were determined. At the same time, its effect on the triglyceride and free fatty acid content in high-fat C. elegans were examined. The results showed that the maximum life span of high-fat C. elegans intervened by fermented rice buckwheat significantly increased by 30.90% (P<0.01), significantly increased motility by 28.57% (P<0.01), and increased egg production (P>0.05). Furthermore, fermented rice buckwheat could significantly increase the antioxidant enzyme activity (P<0.01), reduce malondialdehyde content and ROS levels (P<0.01), and significantly enhance their ability to resist oxidative stress (P<0.01). In addition, fermented rice buckwheat could also significantly reduce the triglyceride and free fatty acid content of high-fat C. elegans, respectively, reduced by 56.58% and 130.54% (P<0.01). In summary, fermented rice buckwheat exhibited a lipid-lowering effect by enhancing resistance to oxidative stress, reducing fat deposition, and improving the antioxidant enzyme activity of high-fat C. elegans.

     

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