6-姜烯酚抗肿瘤机制研究进展

王专; 胡红柳; 陈奇峰; 周洁; 任珍珍; 蒋利和

doi:10.13386/j.issn1002-0306.2022080339

6-姜烯酚抗肿瘤机制研究进展

doi: 10.13386/j.issn1002-0306.2022080339

王专^{1, 2,},
胡红柳³,
陈奇峰²,
周洁²,
任珍珍³,
蒋利和^{1, 2, 3, ,}

1.
广西大学轻工与食品工程学院，广西南宁 530004
2.
广西大学医学院，广西南宁 530004
3.
右江民族医学院基础医学院，广西百色 533000

基金项目: 南宁市青秀区重点研发项目（2020023）；右江民族医学院高层次引进人才项目经费（YY2021sk02）。

详细信息

作者简介:
王专（1998−），男，硕士研究生，研究方向：食品营养学，E-mail：858812187@qq.com

通讯作者:
蒋利和（1976−），男，博士，研究员，研究方向：肿瘤药理学、食品营养学，E-mail：jianglihe@gxu.edu.cn

中图分类号: R15
计量
- 文章访问数: 79
- HTML全文浏览量: 23
- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2022-08-31
- 网络出版日期: 2023-04-18
- 刊出日期: 2023-06-01

Research Progress on Antitumor Mechanism of 6-Shogaol

WANG Zhuan^{1, 2
,},
HU Hongliu³,
CHEN Qifeng²,
ZHOU Jie²,
REN Zhenzhen³,
JIANG Lihe^{1, 2, 3
, ,}

1.
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
2.
Medical College, Guangxi University, Nanning 530004, China
3.
School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China

摘要

摘要: 癌症的发病率与死亡率逐年递增，严重威胁人类健康。6-姜烯酚是生姜中一种主要活性成分，因其具有安全、低毒的优势成为国内外学者关注的热点，6-姜烯酚具有抗炎、抗氧化、抗肿瘤等药理作用，尤其是其抗肿瘤活性日趋成为研究焦点。本文对6-姜烯酚的抗肿瘤作用机制进行综述，主要包括抑制细胞增殖、诱导细胞凋亡、阻滞细胞周期、抑制细胞的迁移和侵袭、影响肿瘤细胞自噬等，以期为6-姜烯酚抗肿瘤的进一步研究、开发和应用提供思路。
- 6-姜烯酚 /
- 抗肿瘤 /
- 作用机制 /
- 研究进展
Abstract: The incidence and mortality of cancer are increasing year by year, which seriously threatens human health. 6-Shogaol, as one of the main active components in ginger, has become the focus of attention in recent years due to its advantages of safety and low toxicity. Moreover, it has anti-inflammatory, antioxidant, anti-tumor and other pharmacological effects. Particularly, its anti-tumor activity has received increasing attention. This paper reviews the anti-tumor mechanism of 6-shogaol, including inhibition of cell proliferation, induction of cell apoptosis, arrest of cell cycle, inhibition of cell migration and invasion, effect of autophagy in tumor cells, etc., in order to provide ideas for further research, development and application of 6-shogaol in anti-tumor.
- 6-shogaol /
- anti-tumor /
- mechanism of action /
- research progress

HTML全文

图 1 6-姜烯酚的化学结构

Figure 1. Chemical structure of 6-shogaol

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图 2 6-姜烯酚在肿瘤细胞中的促凋亡机制

Figure 2. Proapoptotic mechanism of 6-shogaol in tumor cells

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图 3 6-姜烯酚在肿瘤细胞中抑制增殖的作用机制

Figure 3. Mechanism of 6-shogaol inhibiting proliferation in tumor cells

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图 4 6-姜烯酚在肿瘤细胞中抑制迁移和侵袭的作用机制

Figure 4. Mechanism of 6-shogaol in inhibiting migration and invasion of tumor cells

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图 5 6-姜烯酚在肿瘤细胞中影响自噬的作用机制

Figure 5. Mechanism of 6-shogaol affecting autophagy in tumor cells

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表 1 6-姜烯酚的抗肿瘤作用及其机制

Table 1. Antitumor effect and its mechanism of 6-shogaol

药理作用	癌症类型	癌症细胞系或动物模型	作用机制	参考文献
抑制肿瘤细胞增殖	肝癌	Bel-7402	调控Wnt/β-Catenin信号通路	[7]
	肝癌	HepG2	Bax、细胞色素C和Caspase3表达升高	[28]
	乳腺癌	MCF-7和T47D	靶向Notch信号通路，抑制细胞自噬	[8]
	口腔癌	YD-10B和Ca9-22	调控PI3K/AKT/mTOR信号通路	[10]
		OC2	显著增加Ca²⁺含量，影响内质网功能	[63]
		8~10周龄的雄性金色叙利亚仓鼠	NF-κB和AP-1致癌信号来减轻炎症和细胞增殖	[64]
	胰腺癌	Panc-1、AsPC-1、BxPC-3、CAPAN-2、CFPAC-1、MIAPaCa-2和SW1990	通过影响内源性线粒体功能，造成Caspase3释放	[12]
	结肠癌	COLO 205	ROS水平升高，Bax、Fas、FasL表达上调，Bcl-2、Bcl-XL表达下调	[36]
	脂肪肉瘤	SW872和93T449	调控STAT-3、AMPK信号通路，影响内质网功能	[21]
诱导肿瘤细胞凋亡	肝癌	Bel-7402、HepG2	调控Wnt/β-Catenin信号通路	[7]
	肝癌	SMMC-7721	抑制elF-2α的磷酸化，影响内质网应激	[39]
	前列腺癌	LNCaP、DU145和PC3	调控STAT3和 NF-κB信号通路	[16]
	结肠癌	HCT-116、SW-480和HT-29	促进Bax、Caspase3和PARP1蛋白的表达，抑制Bcl-2的表达	[24, 26]
	胃癌	BGC-823	调控EMT信号通路	[29]
	淋巴癌	CCRF-CEM和Nalm-6	调控p53信号通路，影响ROS水平	[32]
	宫颈癌	HeLa和SiHa	通过影响线粒体功能，进而影响ROS，造成Caspase3释放	[27, 54]
阻滞肿瘤细胞周期	前列腺癌	LNCaP、DU145和PC3	p21和p27蛋白表达明显升高，Cyclin D1蛋白表达下降	[16]
	肺癌	H1650、H520和H1975	下调Cyclin D1和Cyclin D3，调控Akt	[47]
	宫颈癌	HeLa	显著下调Cyclin B1、PCNA表达，上调p21蛋白表达	[27]
	结肠癌	HCT-116和SW480	上调p53蛋白和CDK抑制剂表达，下调cdc2蛋白表达	[46]
	淋巴癌	CCRF-CEM和Nalm-6	调控p53信号通路，影响ROS水平	[32]
抑制肿瘤细胞迁移和侵袭	肝癌	Hep3B	调控NF-κB、MAPK信号通路	[51]
	乳腺癌	MDA-MB231	调控Hedgehog/Gli1通路	[52]
	胃癌	BGC-823	调控EMT信号通路	[29]
	口腔癌	YD-10B和Ca9-22	调控Akt信号通路	[10]
	宫颈癌	HeLa	与ECM信号通路相关蛋白表达水平有关	[54]
影响肿瘤细胞自噬	肺癌	A549	阻断Akt-mTOR信号通路，诱导细胞自噬	[65]
	肝癌	Huh7	通过影响p53和ROS水平，导致自噬通量衰减	[59]
	乳腺癌	MCF-7	抑制beclin-I和LC3-II的表达，抑制细胞自噬	[8]
	结肠癌	HT29	形成大量自噬小体，Caspase3和Caspase7活性升高	[57]

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