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中国精品科技期刊2020
刘昕昕,邹萍,朱晨晨,等. 萝卜硫素抗癌作用研究进展[J]. 食品工业科技,2024,45(12):378−386. doi: 10.13386/j.issn1002-0306.2023080072.
引用本文: 刘昕昕,邹萍,朱晨晨,等. 萝卜硫素抗癌作用研究进展[J]. 食品工业科技,2024,45(12):378−386. doi: 10.13386/j.issn1002-0306.2023080072.
LIU Xinxin, ZOU Ping, ZHU Chenchen, et al. Research Progress on Anticancer Effects of Sulforaphane[J]. Science and Technology of Food Industry, 2024, 45(12): 378−386. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023080072.
Citation: LIU Xinxin, ZOU Ping, ZHU Chenchen, et al. Research Progress on Anticancer Effects of Sulforaphane[J]. Science and Technology of Food Industry, 2024, 45(12): 378−386. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023080072.

萝卜硫素抗癌作用研究进展

Research Progress on Anticancer Effects of Sulforaphane

  • 摘要: 癌症是威胁人类健康的头号杀手,其致死率占所有疾病之首。目前,治疗癌症的方式不可避免地存在相关副作用,因此开发安全、有效的抗癌药物成为人们关注的焦点。萝卜硫素作为十字花科植物中生物活性高的天然化合物之一,具有抗癌、抗氧化、抗病毒等特性,其中,治疗癌症的作用机理被人们广泛研究。萝卜硫素可以通过调控细胞周期、抑制细胞的迁移和侵袭、与凋亡相关蛋白的表达抑制癌细胞的生长,也可以通过抗炎和抗氧化,抑制癌细胞的发生和发展。与传统治疗癌症的方法相比,萝卜硫素具有安全、易获得的特点,在抗癌方面有较大的发展潜力。本文综述了近两年萝卜硫素抗癌作用机制,为萝卜硫素的抗癌作用的进一步研究提供了相应的理论依据。

     

    Abstract: Cancer is the leading cause of mortality in human health, with the highest mortality rate among all diseases. Unfortunately, most of the current cancer treatments inevitably come with certain side effects. Therefore, a significant amount of research is focused on the development of safe and effective anticancer drugs. Sulforaphane is one of the most bioactive natural compounds isolated from cruciferous plants. Numerous studies show its anti-cancer, antioxidant, and antiviral properties, as well as its anticancer mechanisms. Sulforaphane can inhibit the growth of cancer cells by regulating the cell cycle, controlling cell migration and invasion, as well as modulating the expression of apoptosis proteins. Some reports also indicate that sulforaphane can impede the development of cancer cells through its anti-inflammatory and antioxidant effects. Compared to most traditional cancer treatment methods, sulforaphane is much safer and more reliable. It is also more readily available and has great anticancer potential. This paper review the anticancer mechanisms of sulforaphane over the past two years and provide the corresponding theoretical basis for further research on the anticancer effects of sulforaphane.

     

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