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中国精品科技期刊2020
罗昭勇,姜艳,余晓历,等. 石斛多糖的结构特征、生物活性、构效关系及产品开发进展[J]. 食品工业科技,2024,45(15):1−14. doi: 10.13386/j.issn1002-0306.2023090148.
引用本文: 罗昭勇,姜艳,余晓历,等. 石斛多糖的结构特征、生物活性、构效关系及产品开发进展[J]. 食品工业科技,2024,45(15):1−14. doi: 10.13386/j.issn1002-0306.2023090148.
LUO Zhaoyong, JIANG Yan, YU Xiaoli, et al. Research Progress on Structure Characteristics, Biological Activity, Structure-Activity Relationship and Product Development of Dendrobium Polysaccharide[J]. Science and Technology of Food Industry, 2024, 45(15): 1−14. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023090148.
Citation: LUO Zhaoyong, JIANG Yan, YU Xiaoli, et al. Research Progress on Structure Characteristics, Biological Activity, Structure-Activity Relationship and Product Development of Dendrobium Polysaccharide[J]. Science and Technology of Food Industry, 2024, 45(15): 1−14. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023090148.

石斛多糖的结构特征、生物活性、构效关系及产品开发进展

Research Progress on Structure Characteristics, Biological Activity, Structure-Activity Relationship and Product Development of Dendrobium Polysaccharide

  • 摘要: 石斛是我国传统名贵的滋补药材,具有益胃生津,滋阴清热的功效,多糖是其主要的活性成分之一。通过查阅国内外近10年相关文献,系统总结常见石斛多糖的结构及生物活性。结果发现石斛多糖具有抗氧化、抗肿瘤、抗炎、免疫调节、调节肠道菌群、降血糖、抗白内障等多种功效,且石斛多糖的生物活性与结构密切相关。研究认为富含甘露糖和葡萄糖的石斛多糖显示出更强的活性,乙酰基含量越高,其免疫活性越强;糖醛酸含量越高,其抗氧化能力越强。主链上的(1→4)-α-D-Glcp和(1→4)-α-D-Manp可能是与石斛多糖活性相关的关键结构,化学修饰如硫酸化、硒化和乙酰化能够增强石斛多糖的活性,而羧甲基化则降低了其活性。本文对近年来国内外关于石斛多糖结构特征、生物活性、产品开发的研究进展进行总结,并阐明其构效关系,旨在为促进石斛多糖的深度开发和应用提供重要的参考依据。

     

    Abstract: Dendrobium is a traditional, valuable, and nourishing medicinal herb in China. It benefits the stomach, promotes fluid production, nourishes yin, and clears heat. Polysaccharides are among the main active ingredients of Dendrobium. By reviewing literature over the past decade, the common structures and biological activities of Dendrobium polysaccharides are systematically summarized. The results illustrate that Dendrobium polysaccharides possess various effects, including antioxidant, antitumor, anti-inflammatory, and immunoregulatory effects, gut microbiota modulation, blood sugar reduction, and anticataract properties. The chemical structures of these polysaccharides are closely related to their biological activities. Previous studies suggest that polysaccharides rich in mannose and glucose exhibit stronger activity, whereas higher acetylation levels enhance immune activity. Higher uronic acid content corresponds to greater antioxidant ability, which may be due to the presence of (1→4)-α-d-Glcp and (1→4)-α-d-Manp on the main chain. Additionally, chemical modifications such as sulfation, selenization, and acetylation can enhance activity, whereas carboxymethylation decreases it. This article summarizes the research progress in recent years on the structure, biological activity, and product development of Dendrobium polysaccharides both domestically and internationally, elucidating the structure-activity relationship, aiming to provide important references for their in-depth development and application.

     

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