• EI
  • Scopus
  • 食品科学与工程领域高质量科技期刊分级目录第一方阵T1
  • DOAJ
  • EBSCO
  • 北大核心期刊
  • 中国核心学术期刊RCCSE
  • JST China
  • FSTA
  • 中国精品科技期刊
  • 中国农业核心期刊
  • CA
  • WJCI
  • 中国科技核心期刊CSTPCD
  • 中国生物医学SinoMed
中国精品科技期刊2020
李煦,储若晴,刘欣茹,等. 负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究[J]. 食品工业科技,xxxx,x(x):1−9. doi: 10.13386/j.issn1002-0306.2024020076.
引用本文: 李煦,储若晴,刘欣茹,等. 负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究[J]. 食品工业科技,xxxx,x(x):1−9. doi: 10.13386/j.issn1002-0306.2024020076.
LI Xu, CHU Ruoqing, LIU Xinru, et al. Study on Sustained Release Properties of Acid Resistant Carboxymethyl Chitosan Gel Microspheres Loaded with Anthocyanins[J]. Science and Technology of Food Industry, xxxx, x(x): 1−9. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024020076.
Citation: LI Xu, CHU Ruoqing, LIU Xinru, et al. Study on Sustained Release Properties of Acid Resistant Carboxymethyl Chitosan Gel Microspheres Loaded with Anthocyanins[J]. Science and Technology of Food Industry, xxxx, x(x): 1−9. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024020076.

负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究

Study on Sustained Release Properties of Acid Resistant Carboxymethyl Chitosan Gel Microspheres Loaded with Anthocyanins

  • 摘要: 为拓宽壳聚糖基水凝胶的应用范围,构筑可食用的ACNs递送体系,采用反相乳液法,以玉米油为连续相,水杨醛(SA)为交联剂,制备了具有抗酸性能的载花色苷(ACNs)羧甲基壳聚糖(CMCS)凝胶微球(ACNs/CMCS-SA),表征了其结构和形貌,研究了其稳定性、溶胀性能和缓释性能。结果表明,ACNs/CMCS-SA具有微米级粒径,表面光滑呈圆形;ACNs/CMCS-SA在酸性条件下稳定性良好,溶胀和缓释过程展现pH响应性;ACNs的释放行为符合Weibull模型,pH7和9时为扩散和骨架溶蚀复合释放机制控制,pH3和5时为菲克扩散和Case II transport(0级-溶胀依赖性释放)联合释放机制控制。ACNs/CMCS-SA制备方法简单,过程绿色;对ACNs展现良好的胃酸保护和肠道释放性能,为环境友好型药物包封材料的开发和ACNs的应用提供了理论和实践参考。

     

    Abstract: This study was aimed at broadening the application range of chitosan hydrogels and constructing an edible ACNs delivery system. The acid resistant carboxymethyl chitosan (CMCS) gel microspheres (ACNs/CMCS-SA) loaded with Anthocyanins (ACNs) were prepared by inversion-phase emulsion method. During the process, corn oil was used as continuous phase and salicylaldehyde (SA) was used as crosslinking agent. The structure and morphology of ACNs/CMCS-SA were characterized. And its stability, swelling ability and sustained release properties were studied. The results showed that ACNs/CMCS-SA had a micron particle size with smooth and round surface. The gel microspheres showed good acid resistance and pH responsiveness during swelling and sustained-release experiments. The sustained release behavior of ACNs conformed to Weibull model. In pH7 and pH9 media, the release process of ACNs was controlled by a combination mechanism of diffusion and skeleton dissolution. In pH3 and 5 media, it was controlled by a combination of Fick diffusion and Case II transport (order 0 grade-swelling dependent release). The preparation method of ACNs/CMCS-SA was simple and green, and the sample exhibited good gastric acid protection and intestinal release performance for ACNs. Therefore, this study lays a theoretical and experimental foundation for the development of environmentally friendly drug encapsulation materials and the application of ACNs.

     

/

返回文章
返回