Determination of chlorimuron-ethyl residue in soybean by solid phase extraction-high performance liquid chromatography-mass spectrometry

A solid phase extraction-high performance liquid chromatography-mass spectrometry method was established for determination the residue of chlorimuron-ethyl herbicide in soybean.Samples were extracted by methanol with ultrasonic, then liquid-liquid partitioned with normal hexane and purified by solid phase extraction.The sample was quantitatively analyzed by high performance liquid chromatography and qualitatively analyzed by high performance liquid chromatography-mass spectrometry.Results showed that:a good linear range from 0.1～ 200.0mg/L with correlation coefficient of above 0.9997 (n=3) was obtained.The extraction recovery were 92.6%～ 95.2%and the relative standard deviation were 1.27%～2.64%.The limit of detection was 10.0μg/kg (S/N=3) .The described method was simple, sensitive and accurate.