Extraction of flavonoids from valerian optimized by response surface method

LU Zhong- ying; CHEN Shi-xue; LI Yan-qing; YAO Yuan-yong; LU Dao-wang; XING Ming-ming

doi:10.13386/j.issn1002-0306.2016.05.030

Article Contents

Article Navigation > Science and Technology of Food Industry > 2016 > (05): 196-200

LU Zhong- ying, CHEN Shi-xue, LI Yan-qing, YAO Yuan-yong, LU Dao-wang, XING Ming-ming. Extraction of flavonoids from valerian optimized by response surface method[J]. Science and Technology of Food Industry, 2016, (05): 196-200. doi: 10.13386/j.issn1002-0306.2016.05.030

Citation:

LU Zhong- ying, CHEN Shi-xue, LI Yan-qing, YAO Yuan-yong, LU Dao-wang, XING Ming-ming. Extraction of flavonoids from valerian optimized by response surface method[J]. Science and Technology of Food Industry, 2016, (05): 196-200. doi: 10.13386/j.issn1002-0306.2016.05.030

Citation:

PDF( 1202 KB)

Extraction of flavonoids from valerian optimized by response surface method

doi: 10.13386/j.issn1002-0306.2016.05.030

Experimental Center of Materials and Chemical Engineering,Tongren University
Institute of Applied Chemistry,Tongren University

Received Date: 2015-06-25

Abstract

Abstract

The extraction process of flavonoid compounds originated from Valeriana ofecnilis( produced from Guizhou province) was investigated using ethanol as the extraction solvent. Method: Four factors,including concentration of Ethanol,ratio of raw material to solvent,extracting temperature and time,were optimized by response surface method.The optimum conditions were as follows: the concentration of ethanol was 53.0%; ratio of material to solvent was 1 ∶ 29 g / m L; extraction temperature was 73 ℃ and extraction time was 26 h. Under the optimum conditions,the difference of between real value of 2.133% and theoretic value in rate of extraction was about 3.5%. Conclusion: Response surface method was a reliable tool to optimize the extraction of flavonoid compounds from Valeriana ofecnilis.
- Valeriana ofecnilis,
- Flavonoids,
- Response surface method,
- Yield

FullText(HTML)

References(14)

References

[1]	周琳,张悦,张静,等.缬草开发前景广阔[J].国土与自然资源研究,2003,(3):91-92.
[2]	张震学,姚新生.药用植物缬草的化学研究进展[J].中国药物化学杂志,2000,10(3):226-230.
[3]	都晓伟,吴军凯.缬草属植物化学成分及药理活性研究进展[J].国外医药,植物药分册,2006,21(1):10-14.
[4]	路洪顺,刘鑫军.缬草的开发价值与栽培技术[J].中国野生植物资源,2002,21(5):61-62.
[5]	Fernández S,Wasowski C,Paladini A C,et al.Sedative and sleep-enhancing properties of linarin,a flavonoid-isolated from Valeriana officinalis.[J].Pharmacology Biochemistry&Behavior,图6乙醇浓度、料液比、浸提温度、浸提时间对黄酮类化合物得率交互影响响应面图Fig.6 Response surface plots showing the effects of four extraction conditions on flavonoids yield2004,77(2):399-404.
[6]	薛存宽,沈凯.缬草主要活性成分的初步研究[J].现代中西药结合杂志,2003,12(9):912-914.
[7]	张振学.药用植物缬草的生物活性研究进展与开发[J].沈阳药科大学学报,20017(3):222-225.
[8]	黄龙.缬草化学成分GC/MS分析研究[J].氨基酸和生物资源,2002,24(2):11-13.
[9]	曹伟国,刘志勤,邵云,等.黄酮类化合物药理作用的研究进展[J].西北植物学报,2003,23(12):2241-2247.
[10]	延玺刘,会青,邹永青,等.黄酮类化合物生理活性及合成研究进展[J].有机化学,2008,28(9):1534-1544.
[11]	魏红,丰帆,陈旭丹,等.4种中药黄酮提取物清除自由基活性的研究[J].天津师范大学学报,2008,28(2):14-17.
[12]	Myers R H,Montgomery D C,Anderson-Cook C M.Response surface methodology:process and product optimization using designed experiments[M]//Response surface methodology:process and product optimization using designed experiments.John Wiley&Sons,2009:284-286.
[13]	赵敏,周欢,姜忠丽,等.桃仁蛋白的提取及功能性质研究[J].农产品加工,2014,(7):42-44.
[14]	赵春艳,敖长金,缪亚娟,等.沙葱中黄酮类化合物分离提取工艺的研究[J]黑龙江畜牧兽医,2010,(1):131-133.