Effect of sulfated polysaccharide from Crassostrea gigas on inhibition and induction of three kinds of carcinoma cell

ZHAO Guan-hua; TONG Chang-qing; LI Wei; QU Min

doi:10.13386/j.issn1002-0306.2017.13.056

ZHAO Guan-hua, TONG Chang-qing, LI Wei, QU Min. Effect of sulfated polysaccharide from Crassostrea gigas on inhibition and induction of three kinds of carcinoma cell[J]. Science and Technology of Food Industry, 2017, (13): 302-306. DOI: 10.13386/j.issn1002-0306.2017.13.056

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Effect of sulfated polysaccharide from Crassostrea gigas on inhibition and induction of three kinds of carcinoma cell

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Abstract

Sulfated polysaccharide from Crassostrea gigsa ( SCGP) was derived by using the chlorosulfonic acid-pyridine method.The inhibitory effects of SCGP on AGS cells, SK-OV-3 cells, and Hep G2 cells were evaluated using CCK-8 assay, and the apoptosis changes were analyzed by flow cytometry.The results showed that SCGP significantly inhibited the growth of three cell.The inhibitory effect of SCGP was better on AGS cells than other cells.The flow cytometry results showed that SCGP could effectively induce the apoptosis of AGS cells.The results suggest that SCGP has inhibitory effect on growth of AGS cells.

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Effect of sulfated polysaccharide from Crassostrea gigas on inhibition and induction of three kinds of carcinoma cell

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