XIAO Yan-hong, XU Qian, ZHOU Xiao-hui, LIU Nan, GOU Zi-wei, LI Su-ting. The improvement effect of Boletus edulis polysaccharides on the liver injury in type 2 diabetic rats[J]. Science and Technology of Food Industry, 2018, 39(11): 297-300,313. DOI: 10.13386/j.issn1002-0306.2018.11.051
Citation: XIAO Yan-hong, XU Qian, ZHOU Xiao-hui, LIU Nan, GOU Zi-wei, LI Su-ting. The improvement effect of Boletus edulis polysaccharides on the liver injury in type 2 diabetic rats[J]. Science and Technology of Food Industry, 2018, 39(11): 297-300,313. DOI: 10.13386/j.issn1002-0306.2018.11.051

The improvement effect of Boletus edulis polysaccharides on the liver injury in type 2 diabetic rats

More Information
  • Received Date: December 11, 2017
  • Available Online: November 26, 2020
  • Objective:The objective of this work was to investigate the effect of Boletus edulis polysaccharide on the liver injury in type 2 diabetes mellitus (T2DM) rats. Methods:The rats were fed with high-fat high-sugar fodder and then injected with streptozocin (STZ) to induce T2DM rat model. Then the T2DM rats were divided randomly into model group, Bolete polysaccharide dose groups (200, 400 mg/kg·bw) and metformin group (200 mg/kg·bw), the normal rats were used as blank control, the normal and model group rats were fed with normal saline. The drugs were infused to stomach of every group of rats and once a day for 4 weeks. Then the levels of blood glucose (GLU) were detected, the liver indexs were calculated;the contents of triglyceride (TG), the activities of Glutamic-pyruvic Transaminase (ALT) and Glutamic oxalacetic Transaminase (AST) in serum were measured;the activities of catalase (CAT), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) and the contents of glutathione (GSH), malonaldehyde (MDA) in the liver were detected. Results:Compared with the model group, three drug groups showed obviously lower contents of GLU, TG and MDA, liver index, activities of ALT and AST;and higher activities of CAT, SOD and GSH-Px, contents of GSH, the difference was significant. Conclusion:Boletus edulis polysaccharide can observably relieve the liver injury in T2DM rats.
  • Cited by

    Periodical cited type(8)

    1. 黄子芬,李晨月,徐柠檬,刘晨,赵海婷,陈勇杏,华燕,郭磊. 真空干燥对美味牛肝菌生物活性成分及其抗氧化活性的影响. 中国食品添加剂. 2024(07): 55-61 .
    2. 由高飞,唐金鑫,孙航,刘士伟,李秋阳,徐萍,于雷,毕云枫. 牛蒡子苷元对四氧嘧啶诱导糖尿病小鼠肝损伤的保护作用. 食品科学. 2022(19): 184-190 .
    3. 秦忠雪,唐嘉阳,阮佳. 食用菌粗多糖测定中粗多糖提取方法的优化研究. 预防医学情报杂志. 2021(02): 275-280 .
    4. 王彤,姜明,郭慧阳. 美味牛肝菌药用价值及产品开发现状. 中国食用菌. 2021(06): 1-5 .
    5. 郭磊,加依达尔·努尔哈买提,岳家梦,尹须,阚欢. 美味牛肝菌总黄酮大孔树脂纯化工艺及抗氧化活性研究. 中国食品添加剂. 2020(01): 85-91 .
    6. 郭磊,钱雪瑞,戴宏玮,徐海,孔德仙,刘丽,阚欢,华燕. 美味牛肝菌不同极性溶剂萃取物的抗氧化及抑菌活性研究. 食品科技. 2020(04): 175-181 .
    7. 杨文娟,程世蕊,马养民,龚频,何亚娟,胡媛,毛跟年. 裂叶荨麻对糖尿病小鼠肝脏损伤的保护作用. 食品工业科技. 2019(11): 313-317 . 本站查看
    8. 李丽,刘忆明,李艳艳,赵中祥,陈志雄. 超声波辅助保山桃红牛肝菌多酚提取工艺及其抗氧化活性. 北方园艺. 2019(23): 129-134 .

    Other cited types(8)

Catalog

    Article Metrics

    Article views (196) PDF downloads (10) Cited by(16)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return