Preparation,Characterization and Performance Analysis of Temperature-Sensitive Starch-Based Polymer Carrier

In this study,a temperature-sensitive polymer carrier(PEG-St-R)was prepared from tapioca starch as a raw material,and was used to explore the mechanism of sustained release and a certain temperature response. First,a hydrophobic tapioca starch polymer(St-R)was prepared with isopropyl glycidyl ether as a hydrophobic group and a temperature-sensitive group,and then polyethylene glycol(mPEG)was used as a hydrophilic group. The temperature-sensitive cassava starch-based polymer(PEG-St-R)was successfully prepared by esterification. The self-assembly behavior of the polymer was characterized by the fluorescent probe method of europium,and the critical micelle concentration(CMC)of the polymer was found to be 0.339 mg/mL. With the help of transmission electron microscope to observe its morphological characteristics,it could be clearly observed that the polymer assembled into a spherical structure,and the particle size of the micelles was further determined. The particle sizes were concentrated around 28 and 122 nm. In addition,by loading the functional component curcumin to investigate its loading performance,when the material was injected with 100 mg and the curcumin was injected with 14 mg,the micelles have the maximum load and the load was 18.47%. At different temperatures,the change of cumulative slow-release was explored. Through the slow-release curve,it could be clearly observed that the cumulative release of micelles in the environment of 37 ℃ reached 43.9% in 60 h. The cumulative release of loaded micelles at 25 ℃ was only 34.7%,showing good temperature sensitivity. It provides a theoretical basis for the functionalization of cassava starch and the preparation of nano-micelle micelles,and provides a good platform for the preparation of temperature-sensitive starch-based polymer carriers.