Volume 43 Issue 12
Jun.  2022
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LI Xin, CHEN Mei, XI Yi, et al. Assessment of Compound Pueraria lobate and Ophiopogon japonicus Tea on Hypoglycaemic Activity[J]. Science and Technology of Food Industry, 2022, 43(12): 347−353. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021100113
Citation: LI Xin, CHEN Mei, XI Yi, et al. Assessment of Compound Pueraria lobate and Ophiopogon japonicus Tea on Hypoglycaemic Activity[J]. Science and Technology of Food Industry, 2022, 43(12): 347−353. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021100113

Assessment of Compound Pueraria lobate and Ophiopogon japonicus Tea on Hypoglycaemic Activity

doi: 10.13386/j.issn1002-0306.2021100113
  • Received Date: 2021-10-14
    Available Online: 2022-04-27
  • Publish Date: 2022-06-08
  • This study aimed to explore the hypoglycaemic effects of the compound Pueraria lobate and Ophiopogon japonicus tea. In this study, the compound Pueraria lobate and Ophiopogon japonicus tea was administered to normal mice. Moreover, a mouse model of hyperglycemia was established, and high (3.0 g/kg BW), medium (2.0 g/kg BW), and low (1.0 g/kg BW) doses of compound Pueraria lobate and Ophiopogon japonicus tea were administered to mice with hyperglycemia. The body weight, blood glucose and glucose tolerance indexes of the mice were detected. In addition, the control group was given placebo and the experimental group was given compound Pueraria lobate and Ophiopogon japonicus tea twice a day, 3 g each time for 60 days in hyperglycemic people. The changes in glycosylated hemoglobin, blood glucose and clinical symptoms were observed. The results showed that compound Pueraria lobate and Ophiopogon japonicus tea had no effect on the body weight and blood glucose in normal mice, but the 2 h blood glucose of hyperglycemic model mice in high and medium dose groups were decreased significantly and extremely significantly, respectively (P<0.05, P<0.01). The area under the blood glucose curve of hyperglycemic model mice in the high dose group was significantly decreased (P<0.05). The results of clinical trials showed compound Pueraria lobate and Ophiopogon japonicus tea could significantly reduce fasting blood glucose and 2 h blood glucose in hyperglycemic people (P<0.01). The effective rate of blood glucose reduction was 70.91%, and the effective rate of improving the symptoms of thirst, polyuria, polydipsia, hunger, fatigue was more than 44.90%. In conclusion, the compound Pueraria lobate and Ophiopogon japonicus tea had hypoglycaemic activity. The study had important significance and value for the prevention and treatment of diabetes and its complications.
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  • [1]
    DEFRONZO R A. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus[J]. Diabetes,2009,58(4):773. doi:  10.2337/db09-9028
    [2]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志,2018,38(4):53. [Diabetes Branch of Chinese Medical Association. Guidelines for prevention and treatment of type 2 diabetes in china (2017)[J]. Chinese Journal of Practical Internal Medicine,2018,38(4):53.

    Diabetes Branch of Chinese Medical Association. Guidelines for prevention and treatment of type 2 diabetes in china (2017) [J]. Chinese Journal of Practical Internal Medicine, 2018, 38(4): 53
    [3]
    ROTH G A, JOHNSON C, ABAJOBIR A, et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015[J]. J Am Coll Cardiol,2017,70(1):1−25. doi:  10.1016/j.jacc.2017.04.052
    [4]
    ORGANIZATION W. WHO Global report on diabetes[J]. Organization,2016:8−10.
    [5]
    BAILEY C J, DAY C. The future of new drugs for diabetes management[J]. Diabetes Research and Clinical Practice,2019,155:107785. doi:  10.1016/j.diabres.2019.107785
    [6]
    LIANG S, GRANATO D, ZOU C, et al. Processing technologies for manufacturing tea beverages: From traditional to advanced hybrid processes[J]. Trends Food Sci Technol,2021,118:431−446. doi:  10.1016/j.jpgs.2021.10.016
    [7]
    MANCINI E, BEGLINGER C, DREWE J, et al. Green tea effects on cognition, mood and human brain function: A systematic review[J]. Phytomedicine,2017,34:26−37. doi:  10.1016/j.phymed.2017.07.008
    [8]
    XING L, ZHANG H, QI R, et al. Recent advances in the understanding of the health benefits and molecular mechanisms associated with green tea polyphenols[J]. Journal of Agricultural and Food Chemistry,2019,67(4):1029−1043. doi:  10.1021/acs.jafc.8b06146
    [9]
    RANA A, RANA S, KUMAR S. Phytotherapy with active tea constituents: A review[J]. Environ Chem Lett,2021,19(3):2031−2041. doi:  10.1007/s10311-020-01154-y
    [10]
    SHANG A, LI J, ZHOU D D, et al. Molecular mechanisms underlying health benefits of tea compounds[J]. Free Radic Biol Med,2021,172:181−200. doi:  10.1016/j.freeradbiomed.2021.06.006
    [11]
    FERREIRA M A, SILVA D M, MORAIS A D, et al. Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults – a review[J]. Obes Rev,2016,17:1316−1328. doi:  10.1111/obr.12452
    [12]
    CHEN T, LIU A B, SUN S, et al. Green tea polyphenols modify the gut microbiome in db/db mice as co-abundance groups correlating with the blood glucose lowering effect[J]. Molecular Nutrition & Food Research,2019,63(8):1801064.
    [13]
    GONG X, JI M, XU J, et al. Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China[J]. Crit Rev Food Sci Nutr,2020,60(14):2303−2326. doi:  10.1080/10408398.2019.1634517
    [14]
    QIAN K, TAN T, OUYANG H, et al. Structural characterization of a homopolysaccharide with hypoglycemic activity from the roots of Pueraria lobata[J]. Food & Function,2020,11(8):7104−7114.
    [15]
    CHEN M H, CHEN X J, WANG M, et al. Ophiopogon japonicus—a phytochemical, ethnomedicinal and pharmacological review[J]. Journal of Ethnopharmacology,2016,181:193−213. doi:  10.1016/j.jep.2016.01.037
    [16]
    YANG L, CHEN J, LU H, et al. Pueraria lobata for diabetes mellitus: Past, present and future[J]. The American Journal of Chinese Medicine,2019,47(7):1−26.
    [17]
    ZHOU Y X, ZHANG H, PENG C. Puerarin: A review of pharmacological effects[J]. Phytotherapy Research,2014,28(7):961−975. doi:  10.1002/ptr.5083
    [18]
    ZHOU H, LI X, SHANG Y, et al. Radical scavenging activity of puerarin: A theoretical study[J]. Antioxidants,2019,8(12):590. doi:  10.3390/antiox8120590
    [19]
    WANG C, YAO J, JU L, et al. Puerarin ameliorates hyperglycemia in HFD diabetic mice by promoting β-cell neogenesis via GLP-1R signaling activation[J]. Phytomedicine,2020,70:153222. doi:  10.1016/j.phymed.2020.153222
    [20]
    KIM J H. Pharmacological and medical applications of Panax ginseng and ginsenosides: A review for use in cardiovascular diseases[J]. Journal of Ginseng Research,2018,42(3):264−269. doi:  10.1016/j.jgr.2017.10.004
    [21]
    SHAO J W, JIANG J L, ZOU J J, et al. Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials[J]. J Funct Food,2020,64:103630. doi:  10.1016/j.jff.2019.103630
    [22]
    WEI Y, YANG H, ZHU C, et al. Hypoglycemic effect of ginsenoside Rg5 mediated partly by modulating gut microbiota dysbiosis in diabetic db/db mice[J]. J Agric Food Chem,2020,68(18):5107−5117. doi:  10.1021/acs.jafc.0c00605
    [23]
    BAI L, GAO J, WEI F, et al. Therapeutic potential of ginsenosides as an adjuvant treatment for diabetes[J]. Frontiers in Pharmacology,2018,9:423. doi:  10.3389/fphar.2018.00423
    [24]
    常松林, 高晓余, 柳双凤, 等. α-亚麻酸对高脂饮食和链脲佐菌素诱导Ⅱ型糖尿病模型小鼠的降血糖作用[J]. 中国食品学报,2021,21(10):86−94. [CHANG S L, GAO X Y, LIU S F, et al. Hypoglycemic effect of α-linolenic acid on high-fat diet and streptozotocin-induced type Ⅱ diabetes model mice[J]. Journal of Chinese Institute of Food Science and Technology,2021,21(10):86−94.

    Chang SL, Gao XY, Liu SF, et. al. Hypoglycemic Effect of α-Linolenic Acid on High-Fat Diet and Streptozotocin-Induced Type Ⅱ Diabetes Model Mice [J]. Journal of Chinese Institute of Food Science and Technology, 2021, 21(10): 86-94.
    [25]
    国家药典委员会. 中国药典 [M]. 北京: 中国医药科技出版社, 2020.

    National pharmacopoeia Commission. Chinese pharmacopoeia[M]. Beijing: China Medical Science and Technology Press, 2020.
    [26]
    AHUJA V, ARONEN P, PRAMODKUMAR T A, et al. Accuracy of 1-hour plasma glucose during the oral glucose tolerance test in diagnosis of type 2 diabetes in adults: A meta-analysis[J]. Diabetes Care,2021,44(4):1062−1069. doi:  10.2337/dc20-1688
    [27]
    FLOCH J-P L, ESCUYER P, BAUDIN E, et al. Blood glucose area under the curve: Methodological aspects[J]. Diabetes Care,1990,13(2):172−175. doi:  10.2337/diacare.13.2.172
    [28]
    刘韫滔, 黄伟民, 李诚, 等. 木姜叶柯全发酵茶的活性成分及其降血糖活性研究[J]. 食品与发酵工业,2020,416(20):57−64. [LIU Y T, HUANG W M, LI C, et al. Active components and hypoglycemic activities of the whole fermentation tea of Lithocarpus litseifolius[J]. Food and Fermentation Industries,2020,416(20):57−64.

    Liu YT, Huang WM, Li C, et al. Active components and hypoglycemic activities of the whole fermentation tea of Lithocarpus litseifolius [J]. Food and Fermentation Industries, 2020, 416(20): 57-64.
    [29]
    LI H, FANG Q, NIE Q, et al. Hypoglycemic and hypolipidemic mechanism of tea polysaccharides on type 2 diabetic rats via gut microbiota and metabolism alteration[J]. Journal of Agricultural and Food Chemistry,2020,68(37):10015−10028. doi:  10.1021/acs.jafc.0c01968
    [30]
    KUO H J, HUANG Y C, GARCÍA A A. Fatigue, pain, sleep difficulties, and depressive symptoms in Mexican Americans and Chinese Americans with type 2 diabetes[J]. J Immigr Minor Health,2020,22(5):895−902. doi:  10.1007/s10903-020-01001-w
    [31]
    HADDAD N G, NABHAN Z M, EUGSTER E A. Incidence of central diabetes insipidus in children presenting with polydipsia and polyuria[J]. Endocr Pract,2016,22(12):1383−1386. doi:  10.4158/EP161333.OR
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