Abstract: Sea cucumber is rich in protein, polysaccharides, unsaturated fatty acids, saponins, minerals, vitamins and various nutrients and bioactive ingredients, showing a variety of nutrition value and health effects. Therefore, there has been a traditional habit of using sea cucumber as food and medicine in China and some Asian countries. Sea cucumber peptides possess a variety of bioactivities such as immunity enhancing ability, anti-fatigue, anti-aging, anti-inflammatory, and their application has been expanded. With the changing concept of nutritious diet and skin health maintenance, sea cucumbers have attracted much attention for their high edible value and rich collagen. In this paper, the preparation, deodorization, separation and purification methods of sea cucumber peptides are summarized, and the research progress of sea cucumber peptides stability and skin care related effects such as moisturizing, antibacterial, anti-inflammatory, anti-aging, whitening and sunscreen, promoting tissue repair are reviewed. Finally, the scientific problems to be solved in the study of sea cucumber peptides are discussed, and the development potential of sea cucumber peptides in new application directions is prospected, providing a reference for the research of sea cucumber deep processing and sea cucumber peptide products.