Abstract: In this study, probe-type ultrasound assisted natural deep eutectic solvents (NADES) were used for the extraction of Cerasus humilis polyphenols (CHP). The extraction parameters were optimised by single factor and orthogonal experiments, and the optimal resin was selected based on adsorption/desorption capacity. The adsorption mechanism of the resin on CHP was investigated by resin adsorption kinetics and isothermal equilibrium experiments, and the composition and antioxidant activity of CHP were analysed. The results showed that choline chloride and citric acid were the optimal solvents for extracting CHP with a solid-liquid ratio of 1:50 (g/mL), ultrasonic power of 420 W, NADES moisture content of 35% (V/V) and ultrasonic extraction for 30 min. The CHP extraction content reached 491.25 mg/100 g dry weight. AB-8 had favorable adsorption/desorption capacity and desorption rate (80.20%, 57.81% and 46.36%, respectively) and was selected as the optimal resin. The adsorption process was monolayer adsorption, and low temperature was conducive to adsorption. Seventeen polyphenolic compounds, including chlorogenic acid, catechins and epicatechins, were identified from the purified extract by LC-MS². In addition, CHP exhibited strong antioxidant activity with SC₅₀ values of 0.059 and 0.032 mg/mL for DPPH and ABTS⁺ radical scavenging, respectively. This study may provide a theoretical basis for the green extraction and application of functional agents in Cerasus humilis.