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中国精品科技期刊2020
丁龙艳,刘茜,刘燕菊,等. 基于肠道微生态探讨膳食纤维改善高脂血症的研究进展J. 食品工业科技,2026,47(11):1−7. doi: 10.13386/j.issn1002-0306.2025060016.
引用本文: 丁龙艳,刘茜,刘燕菊,等. 基于肠道微生态探讨膳食纤维改善高脂血症的研究进展J. 食品工业科技,2026,47(11):1−7. doi: 10.13386/j.issn1002-0306.2025060016.
DING Longyan, LIU Qian, LIU Yanju, et al. Research Progress on Dietary Fiber Improving Hyperlipidemia Based on Gut MicrobiotaJ. Science and Technology of Food Industry, 2026, 47(11): 1−7. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025060016.
Citation: DING Longyan, LIU Qian, LIU Yanju, et al. Research Progress on Dietary Fiber Improving Hyperlipidemia Based on Gut MicrobiotaJ. Science and Technology of Food Industry, 2026, 47(11): 1−7. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025060016.

基于肠道微生态探讨膳食纤维改善高脂血症的研究进展

Research Progress on Dietary Fiber Improving Hyperlipidemia Based on Gut Microbiota

  • 摘要: 高脂血症(Hyperlipidemia,HP)作为一种临床常见的慢性代谢性疾病,近年来发病率呈快速上升趋势,然而降脂类西药存在耐受性差且副作用多等问题。研究发现,膳食纤维作为七大营养素之一,可通过调节肠道菌群及代谢产物、修复肠道屏障等途径干预HP的发生与发展。本文概述了肠道微生态平衡在HP发病机制中的作用,分析了不同种类膳食纤维对肠道菌群组成、结构和功能的影响。同时,深入探讨了膳食纤维如何通过调节肠菌代谢产物,特别是短链脂肪酸和胆汁酸,进而影响脂质代谢及炎症反应,为其从肠道微生态角度调控脂质代谢紊乱提供理论依据。

     

    Abstract: Hyperlipidemia (HP) is a common chronic metabolic disease with a rapidly increasing incidence reported in recent years. However, lipid-lowering medications are often associated with poor tolerance and numerous adverse effects. Studies have shown that dietary fiber, one of the seven major nutrients, can intervene in the onset and progression of HP through mechanisms, such as intestinal microbiota and metabolic product regulation and intestinal barrier repair. This review addresses the role of the gut microbiota balance in HP pathogenesis; analyzes the effects of different types of dietary fiber on the composition, structure, and function of the gut microbiota; and explores how dietary fiber regulates gut microbiota metabolites, particularly short-chain fatty acids and bile acids, thereby influencing lipid metabolism and inflammatory responses. Collectively, this provides a theoretical basis for the regulation of lipid metabolism disorders from the perspective of gut microbiota balance.

     

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