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中国精品科技期刊2020
袁玉芹,迟涵蔚,梁淑蕾,等. 海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究J. 食品工业科技,2026,47(11):1−11. doi: 10.13386/j.issn1002-0306.2025120146.
引用本文: 袁玉芹,迟涵蔚,梁淑蕾,等. 海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究J. 食品工业科技,2026,47(11):1−11. doi: 10.13386/j.issn1002-0306.2025120146.
YUAN Yuqin, CHI Hanwei, LIANG Shulei, et al. Structural Characterization of Sodium Alginate-Albumen Gel Beads for Loading of Fe(Ⅲ): Loading PerformanceJ. Science and Technology of Food Industry, 2026, 47(11): 1−11. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025120146.
Citation: YUAN Yuqin, CHI Hanwei, LIANG Shulei, et al. Structural Characterization of Sodium Alginate-Albumen Gel Beads for Loading of Fe(Ⅲ): Loading PerformanceJ. Science and Technology of Food Industry, 2026, 47(11): 1−11. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025120146.

海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究

Structural Characterization of Sodium Alginate-Albumen Gel Beads for Loading of Fe(Ⅲ): Loading Performance

  • 摘要: 为构建新型矿物质元素递送载体,本文以海藻酸钠和蛋清为原料制备了海藻酸钠-蛋清复合凝胶珠(SA-A),并进一步合成了载铁型复合凝胶珠(SA-A-Fe),通过结构表征评估其理化性能及载铁能力。结果表明,海藻酸钠和蛋清之间主要通过非共价作用结合,SA-A凝胶珠的粘弹性和热稳定性优于海藻酸钠凝胶珠(SA),装载铁后的凝胶珠粘弹性和热稳定性得到进一步加强。SA-A凝胶珠对Fe3+的吸附更符合拟二阶动力学模型,表明化学吸附可视为Fe3+吸附的主要机制。颗粒内扩散模型的第(Ⅰ)吸附阶段中Fe3+从水中快速扩散至凝胶珠外表面,是Fe3+在凝胶珠吸附动力学中的限速步骤,随后逐渐发生颗粒内扩散最终达到平衡。整个过程主要发生在凝胶珠的非均质表面并显示多层吸附特征。体外模拟释放结果表明SA-A作为壁材可以延缓Fe3+在胃液中过早释放,同时在模拟肠消化过程中释放显著增加,证明SA-A-Fe凝胶珠具有独特的缓释特性与良好的稳定性。本研究证实SA-A凝胶珠具有良好的结构稳定性与Fe3+负载能力,并能在模拟胃肠液环境中实现铁离子的控释释放,有望作为新型补铁剂载体,为新型补铁剂的开发利用提供参考。

     

    Abstract: To develop a novel carrier for mineral delivery, sodium alginate-albumen composite gel beads (SA-A) were prepared using sodium alginate and albumen as substrates, and further iron-loaded composite gel beads (SA-A-Fe) were synthesized. The physicochemical properties and Fe(Ⅲ) loading capacity of the beads were evaluated through structural characterization. Results revealed that the binding between sodium alginate and albumen was governed by non-covalent interaction. Compared to pure sodium alginate beads (SA), the SA-A beads exhibited markedly enhanced viscoelasticity and thermal stability, with both viscoelastic and thermal properties further improved upon Fe(Ⅲ) loading. The adsorption of Fe(Ⅲ) was more in line with the pseudo-second-order kinetic model, indicating that chemisorption could be considered as the dominant mechanisms of Fe(Ⅲ) adsorption. In the first adsorption stage of the intraparticle diffusion model, the rapid diffusion of Fe(Ⅲ) from the aqueous phase to the bead surface was identified as the rate-limiting step, followed by gradual intra-particle diffusion until equilibrium was attained. The adsorption process was characterized by heterogeneous surface sites and multilayer adsorption behavior. In vitro release studies demonstrated that the SA-A bead, as a wall material, effectively delayed premature Fe(Ⅲ) release in simulated gastric fluid while promoting sustained release under simulated intestinal conditions, demonstrating that the SA-A-Fe gel beads possess unique sustained-release characteristics and good stability. Collectively, these findings demonstrate that SA-A beads possess excellent structural integrity and high Fe(Ⅲ) loading efficiency, with controlled iron ion release under simulated gastric and intestinal fluid conditions, highlighting their promise as an effective carrier for iron delivery. This work provides a scientific foundation for the rational design and application of novel iron supplements.

     

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