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中国精品科技期刊2020
袁玉芹,迟涵蔚,梁淑蕾,等. 海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究J. 食品工业科技,2026,47(11):185−195. doi: 10.13386/j.issn1002-0306.2025120146.
引用本文: 袁玉芹,迟涵蔚,梁淑蕾,等. 海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究J. 食品工业科技,2026,47(11):185−195. doi: 10.13386/j.issn1002-0306.2025120146.
YUAN Yuqin, CHI Hanwei, LIANG Shulei, et al. Structural Characterization of Sodium Alginate-Albumen Gel Beads and Their Fe3+ Loading PerformanceJ. Science and Technology of Food Industry, 2026, 47(11): 185−195. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025120146.
Citation: YUAN Yuqin, CHI Hanwei, LIANG Shulei, et al. Structural Characterization of Sodium Alginate-Albumen Gel Beads and Their Fe3+ Loading PerformanceJ. Science and Technology of Food Industry, 2026, 47(11): 185−195. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2025120146.

海藻酸钠-蛋清凝胶珠的结构表征及其对Fe3+的装载性能探究

Structural Characterization of Sodium Alginate-Albumen Gel Beads and Their Fe3+ Loading Performance

  • 摘要: 为构建新型矿物质元素递送载体,本文以海藻酸钠和蛋清为原料制备了海藻酸钠-蛋清复合凝胶珠(SA-A),并进一步合成了载铁型复合凝胶珠(SA-A-Fe),通过结构表征评估其理化性能及载铁能力。结果表明,海藻酸钠和蛋清之间主要通过非共价作用结合,SA-A凝胶珠的粘弹性和热稳定性优于海藻酸钠凝胶珠(SA),装载铁后的凝胶珠粘弹性和热稳定性得到进一步加强。SA-A凝胶珠对Fe3+的吸附更符合拟二阶动力学模型,表明化学吸附可视为Fe3+吸附的主要机制。颗粒内扩散模型的第(Ⅰ)吸附阶段中Fe3+从水中快速扩散至凝胶珠外表面,是Fe3+在凝胶珠吸附动力学中的限速步骤,随后逐渐发生颗粒内扩散最终达到平衡。整个过程主要发生在凝胶珠的非均质表面并显示多层吸附特征。体外模拟释放结果表明SA-A作为壁材可以延缓Fe3+在胃液中过早释放,同时在模拟肠消化过程中释放显著增加,证明SA-A-Fe凝胶珠具有独特的缓释特性与良好的稳定性。本研究证实SA-A凝胶珠具有良好的结构稳定性与Fe3+负载能力,并能在模拟胃肠液环境中实现铁离子的控释释放,有望作为新型补铁剂载体,为新型补铁剂的开发利用提供参考。

     

    Abstract: To develop a novel carrier for mineral delivery, sodium alginate-albumen composite gel beads (SA-A) were prepared using sodium alginate and albumen as substrates, and further iron-loaded composite gel beads (SA-A-Fe) were synthesized. The physicochemical properties and Fe3+ loading capacity of the beads were evaluated through structural characterization. Results revealed that the binding between sodium alginate and albumen was governed by non-covalent interaction. Compared to pure sodium alginate beads (SA), the SA-A beads exhibited markedly enhanced viscoelasticity and thermal stability, with both viscoelastic and thermal properties further improved upon Fe3+ loading. The adsorption of Fe3+ was more in line with the pseudo-second-order kinetic model, indicating that chemisorption could be considered as the dominant mechanisms of Fe3+ adsorption. In the first adsorption stage of the intraparticle diffusion model, the rapid diffusion of Fe3+ from the aqueous phase to the bead surface was identified as the rate-limiting step, followed by gradual intra-particle diffusion until equilibrium was attained. The adsorption process was characterized by heterogeneous surface sites and multilayer adsorption behavior. In vitro release studies demonstrated that the SA-A bead, as a wall material, effectively delayed premature Fe3+ release in simulated gastric fluid while promoting sustained release under simulated intestinal conditions, demonstrating that the SA-A-Fe gel beads possess unique sustained-release characteristics and good stability. Collectively, these findings demonstrate that SA-A beads possess excellent structural integrity and high Fe3+ loading efficiency, with controlled iron ion release under simulated gastric and intestinal fluid conditions, highlighting their promise as an effective carrier for iron delivery. This work provides a scientific foundation for the rational design and application of novel iron supplements.

     

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