Abstract: To promote the development and high-value utilization of Eucommia ulmoides leaves (EUL), a substance with medicinal and dietary properties, this study optimized the processing technology for Eucommia ulmoides leaves black tea (BT) and investigated its multi-organ protective effects and mechanisms against acute alcohol intoxication. Sensory quality was used as the primary evaluation metric to determine the optimal BT processing parameters through single-factor experiments. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was employed to characterize the compositional changes and relative content variations of major constituents in EUL before and after processing. The in vitro antioxidant activity was evaluated using the ABTS and DPPH assays, while its in vivo protective effects and anti-inflammatory mechanisms were investigated via an acute alcohol intoxication mouse model. After processed using the optimal parameters as 8 hours of natural withering at room temperature, 8 hours of fermentation at 30 ℃, and drying at 110 ℃ until moisture content ≤5%, BT with a sensory score of 85.78 was yielded. Compared to unprocessed EUL, 54 compounds were significant elevated in BT, including 9 key flavor compounds and 17 major bioactive compounds, while 34 compounds (e.g., 3-dehydrocoumaric acid) were reduced. In vitro antioxidant assays confirmed that BT exhibited markedly superior antioxidant activity compared to raw EUL. In vivo experiments demonstrated that BT treatment significantly reduced the relative expression levels of inflammatory cytokines IL-6, TGF-β1, and TNF-α in liver tissue from acutely alcohol-intoxicated mice, with the most pronounced inhibition observed for IL-6, thereby attenuating systemic inflammatory responses. Histopathological observations revealed that BT ameliorated alcohol-induced liver damage, including fatty vacuolar degeneration and hepatocyte reduction. It also mitigated neuronal abnormalities in the brain, such as pyknosis and hyperchromasia, and alleviated colonic inflammation while restoring crypt architecture. In summary, BT prepared via the optimized process not only exhibits markedly enhanced in vitro antioxidant activity but also effectively modulates alcohol-induced damage and inflammatory responses in the liver, brain, and colon, demonstrating its promising potential as a functional product for mitigating acute alcohol intoxication. This study provided a technical foundation and theoretical insights for the high-value utilization of EUL and development of BT.